| 侯学敬 张佳慧 车艺兰 由军 肖珊珊 刘丽晓.甲亢孕妇血清25-羟维生素D水平对42 天婴儿骨密度影响的研究[J].,2014,14(13):2542-2531 |
| 甲亢孕妇血清25-羟维生素D水平对42 天婴儿骨密度影响的研究 |
| Study on Serum25 Hydroxy Vitamin D of Pregnant Women withHyperthyroidism and Bone Mineral Density of 42-Day-Old Infants |
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| DOI： |
| 中文关键词: 甲状腺功能亢进 孕妇 婴儿 25(OH)D3 骨密度 |
| 英文关键词: Hyperthyroidism Pregnant women Infants 25-(OH)D3 Bone mineral density |
| 基金项目:黑龙江省科技攻关课题基金（GA07C303109） |
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| 中文摘要: |
| 目的：探讨甲状腺功能亢进（甲亢）孕妇经治疗后，其体内25- 羟维生素D（25-(OH)D3）水平对42 天婴儿胫骨声波的传导速
度（speed of sound, SOS）值、骨代谢生化指标的影响。方法：选取我院门诊及住院确诊的甲亢孕妇40 例为甲亢组（T 组），随机抽取
健康孕妇40 例作为对照组（C 组），甲亢组给予丙硫氧嘧啶治疗后，监测两组孕妇25-(OH)D3水平与生后42 天婴儿的胫骨SOS
值、骨代谢生化指标，并进行对比观察、统计分析。结果：甲亢组孕妇在产后42 天体内25-(OH)D3的水平比其在产后第1 天升高
（P<0.05），甲亢组孕妇在产后42 天体内25-(OH)D3水平接近对照组（P >0.05），在产后42 天婴儿的胫骨SOS 值接近对照组（P >0.
05），甲亢组产后42 天婴儿的血清钙(Ca) 及血清碱性磷酸酶（AKP）接近对照组（P >0.05）。结论：甲亢组孕妇给予丙硫氧嘧啶治疗
后，甲状腺功能恢复正常，其体内25-(OH)D3水平升高，所产42 天婴儿的骨密度也随着升高。 |
| 英文摘要: |
| Objective:To investigate the relations of 25 hydroxy vitamin D (25-(OH)D3) levels in the treated pregnant women with
hyperthyroidism with the tibial speed of sound (SOS) and biochemical markers of bone metabolism in 42-day-old infants.Methods:40
cases of pregnant women with hyperthyroidism (group T) from inpatient and outpatient department of our hospital were selected, and 40
cases of healthy pregnant women were randomly selected as the control (group C). The hyperthyroidism were treated with propylthiouracil
therapy. Both groups were monitored for the 25-(OH)D3 levels in the mother and the tibial SOS and biochemical markers of bone
metabolismin 42-day-old infants.Results:Compared with the postpartumday 1, the 25-(OH)D3 levels on postpartumday 42 was increased
in the mother from hyperthyroid group (P<0.05) and similar to the level in the control group (P >0.05). Tibial SOS, serum calcium (Ca)
and serumalkaline phosphatase (AKP) in 42-day-old infants born by the hyperthyroid mothers showed no difference compared with the
infants born by the control mothers (P>0.05).Conclusion:Pregnant women with hyperthyroidismwere given PTU treatment, whose thyroid
function returned to normal, whose body of 25-(OH)D3 levels increased, bone mineral density of 42 days infants also increased. |
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