| 章雪莲 饶丽娟 李名花 余丽辉 魏馨.复发性自然流产患者外周血中Th17 及Treg细胞及其效应因子的变化[J].,2014,14(11):2055-2057 |
| 复发性自然流产患者外周血中Th17 及Treg细胞及其效应因子的变化 |
| The Changes of Th17 and Treg Cells in the Recurrent SpontaneousAbortion Patients |
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| DOI： |
| 中文关键词: 复发性自然流产 Th17 细胞 调节性T 细胞 |
| 英文关键词: Recurrent Spontaneous Abortion Th17 Cell Treg Cell |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨复发性自然流产患者外周血中Th17、Treg细胞以及相关细胞因子的变化。方法：选择复发性自然流产患者25
例，正常妊娠妇女25 例以及正常非妊娠育龄妇女25 例，流式细胞术测定外周血中Th17 和Treg 细胞数量，ELISA 法测定血清
IL-10、TGF-茁及IL-17 的浓度。结果：复发性自然流产患者外周血中Th17 细胞百分率显著高于正常妊娠以及正常非孕妇女
(P<0.05)，Treg 细胞百分率显著低于正常非孕妇女(P<0.05)，但与正常妊娠妇女相比无显著性差异(P>0.05)；复发性自然流产患者
外周血IL-10及TGF-茁水平显著低于正常妊娠妇女以及正常非孕妇女(P<0.05)，而IL-17 水平显著高于正常妊娠妇女以及正常非
孕妇女(P<0.05)。结论：外周血Th17 细胞数和IL-17 水平的升高以及抑制性细胞因子IL-10 和TGF-beta水平的下降可能是复发性自
然流产发生的重要原因。 |
| 英文摘要: |
| Objective:T he changes of Th17 cells, Treg cells and related cytokines in peripheral blood of recurrent spontaneous
abortion (RSA) patients was discussed. Methods:25 recurrent spontaneous abortion patients, 25 normal pregnant women and 25 normal
non-pregnant women at childbearing age were selected in this study. The numbers of Th17 and Treg cell in peripheral blood were
measured by flow cytometry. The concentrations of serum IL-10, TGF- beta, and IL-17 were determined by ELISA kits. Results: The
percentage of Th17 cell in peripheral blood of RSA patients was significantly higher than that of normal pregnant and normal
non-pregnant women(P<0.05), the percentage of Treg cell in peripheral blood of RSA patients was significantly lower than that in normal
non-pregnant women(P<0.05), but there was no significant difference in comparison with normal pregnanct women(P>0.05). The levels
of serum IL-10 and TGF-茁of RSA patients were significantly lower than that of normal pregnant women and normal non-pregnant
women(P<0.05), while IL-17 level was significantly higher than that in normal pregnant and non-pregnant women(P<0.05).Conclusion:The number of Th17 cell, IL-17 level and serum level of inhibitory cytokines IL-10 and TGF-beta may play an important role in the
development of recurrent spontaneous abortion. |
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