| Objective:To investigate the target-controlled infusion intravenous anesthesia and epidural anesthesia on immune
function of the patients with colorectal cancer resection.Methods:72 patients with colorectal cancer resection were divided into observation
group and control group, and 36 cases were in each group, the observation group was given target controlled infusion intravenous
anesthesia while the control group was received lumbar epidural anesthesia, the operative time, blood loss, and immunoglobulin levels
(IgG, IgA, IgM), serum levels of interleukin-6 (IL-6), tumor necrosis factor-a levels (TNF -a) and T-cell subsets (CD3, CD4) levels were
compared between the two groups.Results:The mean operative time of the observation group was (130.5± 11.7) min, mean intraoperative
blood loss was (271.3± 37.8) mL, and it showed no significant difference compared with the control group (P>0.05); the IgG, IgA
and IgMat T1, T2, T3 and T4 levels had no significant difference (P>0.05); IL-6, TNF-a, CD3 and CD4 after anesthesia changed significantly
compared with T1, the differences were statistically significant (P<0.05), and changes in the observation group was significant than
the control group, the difference was statistically significant (P<0.05).Conclusion:Target-controlled infusion intravenous anesthesia and
epidural anesthesia on immune function for patients with colorectal cancer resection are present inhibition, and it can suppress immune
function-based, and the inhibition of epidural anesthesia is low, which is should be widely applied in clinical. |
