| 王培欢 吴高义 李吉国 陈晨 朱国雄.睡眠剥夺对大鼠行为学及咀嚼肌肌电图的影响[J].,2014,14(9):1645-1647 |
| 睡眠剥夺对大鼠行为学及咀嚼肌肌电图的影响 |
| Effect of Sleep Deprivation on Praxiology and Electromyogramin Rat |
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| DOI： |
| 中文关键词: 睡眠剥夺 颞下颌关节紊乱病 咀嚼肌 肌电图 |
| 英文关键词: Sleep deprivation TMD Masticatory muscles Electromyogram |
| 基金项目:第48 批中国博士后科学基金项目(2010048152)；第4 批中国博士后特别资助基金(201104771)；
山东省中青年科学家奖励基金(2011BSBO2001)；济南军区总医院院长基金项目(2010M08) |
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| 中文摘要: |
| 目的：颞下颌关节紊乱病是口腔科的一种常见病和多发病，精神心理因素是颞下颌关节紊乱病的一个主要病因。本文通过
观察睡眠剥夺对大鼠行为学及咀嚼肌肌电图的影响，探讨睡眠剥夺在颞下颌关节紊乱病发病中的作用。方法：35 只Wistar大鼠，
随机分为5 组：睡眠剥夺1d 组、5d 组、9d 组、正常对照组和大平台对照组。采用改良多平台睡眠剥夺法（modified multiple
plat-formmethod，MMPM）建立大鼠SD 模型，观察大鼠行为学及咀嚼肌肌电图的变化。结果：睡眠剥夺1d 组和5d 组在旷场实验
水平得分和垂直得分上均高于对照组，而睡眠剥夺9d 组均低于对照组；睡眠剥夺1d、5d 和9d 组在松弛状态和紧咬状态时颞肌
前后束及咬肌的电位均明显高于对照组，且两侧无明显差别，同时，睡眠剥夺组双侧颞肌和咬肌的肌电图静息期较对照组显著延
长。结论：睡眠剥夺可使大鼠行为学发生改变并对咀嚼肌肌电图造成影响，这可能是颞下颌关节紊乱病的病因之一，为我们对颞
下颌关节紊乱病的预防和治疗提供了一定的理论指导。 |
| 英文摘要: |
| Objective:Temporomandibular joint disorders (TMD) is a common and frequently-occurring disease in Department of
Stomatology, and psychological factor is one of the main causes of the disease. This article to observe the influence of sleep deprivation
upon the praxiology and electromyography (EMG) of masticatory muscle, and to investigate the effect of sleep deprivation upon the pathogenesis
of TMD.Methods:35 Wistar rats were randomly divided into five groups: normal cage group, tank cage group, SD1d group,
SD5d group, and SD9d group. Then "modified multiple plat-form method" was used to develop rat sleep deprivation model followed by
detection of praxiology and electromyography of masticatory muscle.Results:In the open-field test, level scores and vertical scores of SD
1d and 5d group were higher than that of control group, and SD 9d group was lower than control group. The electric potentials of
temporalis and masseter at both lax and biting status 1, 5 and 9 days after model establishment were significantly higher compared with
those of control group. No evident difference was found between bilateral sides. Meanwhile, the resting periods of bilateral temporalis
and masseter in sleep deprivation group, as shown on EMG, were significantly prolonged compared with those in control group.Conclusion:Sleep deprivation is able to affect the praxiology and EMG of masticatory muscle, serving as a potential etiology of TMD.
This will provide some theoretical guidance for the prevention and treatment of TMD. |
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