| 王冰李炳蔚苑晓晨李爱玲修瑞娟△.微血管自律运动在高血压发生发展中的变化和意义[J].,2014,14(8):1580-1582 |
| 微血管自律运动在高血压发生发展中的变化和意义 |
| Microvascular Vosomotion Changes in Occurrence and Developmentof Hypertension |
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| DOI： |
| 中文关键词: 微血管自律运动 高血压 内皮 膜电位 |
| 英文关键词: Vasomotion Hypertension Endothelium Membrane potential |
| 基金项目: |
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| 中文摘要: |
| 摘要：微循环的异常，包括微血管的稀疏和（或）微血管结构的改变，可能参与了高血压的发生发展，是造成终末器官缺血和功能
障碍直至衰竭的主要原因之一。根据文献报道，微血管自律运动调控血流动力学的同时还参与信息传递并适时作出反应，改善组
织灌注不足、缺血、缺氧,缓解外周压力。已有研究发现，高血压发生发展过程中，微血管自律运动频率和振幅呈现复杂的变化,可
能与内皮细胞功能不足、细胞间缝隙连接减少、平滑肌细胞钙离子内流增多及钙池功能异常引起膜电位改变等有关,本文将从微
循环的角度阐述高血压状态下微血管自律运动的变化并对其机制做一简要概述。 |
| 英文摘要: |
| ABSTRACT:Microcirculatory abnormalities including microvascular rarefaction and (or) structural changes might be involved in
occurrence and development of hypertension and is a major cause of end-organ damage. Many results have been emerged that
microvascular vasomotion not only played a significant role in hemodynamic of blood circulating system, but also participated in
information signaling, improving organ perfusion inadequacy, ischemia-hypoxia and peripheral vascular resistance. The relationship
between hypertension and micro vascular vasomotion is well established showing complicated changes both in amplitude and frequency
at different development stage of hypertension. Furthermore, mounting evidences about regulatory mechanisms for complicated changes
in hypertension have been sprouted up that it might be related with endothelium dysfunction, limited number of gap junctions and
membrane potential calcium influx. Therefore, one important perspective might be provided by microvascular vasomotion to investigate
the pathophysiological changes in hypertension, and the underlying mechanisms would be briefly reviewed. |
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