| 徐丽华 宁春平 王建红 房世保.声触诊组织定量技术鉴别诊断甲状腺微小癌的价值 *[J].,2014,14(6):1104-1108 |
| 声触诊组织定量技术鉴别诊断甲状腺微小癌的价值 * |
| The Value of Virtual Touch Tissue Quantification Technique in DifferentialDiagnosis of Thyroid Microcarcinomas* |
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| DOI： |
| 中文关键词: 声触诊组织定量 弹性成像 甲状腺结节 微小癌 |
| 英文关键词: Virtual touch tissue quantification Elastography Thyroid nodule Microcarcinoma |
| 基金项目:青岛市科技局民生计划项目 （13-1-3-36-nsh ） |
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| 中文摘要: |
| 摘要 目的： 声触诊组织定量技术(VTQ)是一种新的弹性成像方法， 能够定量、 无创地评价组织硬度信息。本文的研究目的是探讨
声触诊组织定量技术在鉴别诊断甲状腺微小癌(TMCs)中的应用价值。方法： 应用 VTQ 技术对 110 例共 114 个结节(最大直径≤
1 cm)进行检测， 获取并分析结节及周边甲状腺组织的横向剪切波速度 （ SWV ）。利用 ROC 曲线对测量结果进行分析， 评价 VTQ
技术的诊断价值并确定最佳诊断界值。 结果： 114 个结节中良性结节 32 个(30 个为结节性甲状腺肿， 2 个为腺瘤)， 恶性结节 82 个
(均为乳头状癌)。甲状腺良性结节及周边甲状腺组织的 SWV 平均值分别为(2.30± 0.49) m/s、 (2.08± 0.40) m/s， 恶性结节及周边甲
状腺组织的 SWV 平均值分别为(3.12± 0.97) m/s、 (2.06± 0.46) m/s。恶性结节的 SWV 值明显高于良性结节， 两者之间差异具有统
计学意义(t=5.911， P＜ 0.0001)； 恶性结节与其周边甲状腺组织比较有显著差异(P＜ 0.0001)； 而良性结节与其周边甲状腺组织无统
计学差异(P＞ 0.05)。 ROC 曲线下面积为 0.833，以 2.30 m/s 诊断界值点时， 敏感度、 特异度分别为 90.2%、 62.5%。 结论： 甲状腺恶性
结节的 SWV 值明显高于良性结节。VTQ 技术能够提供组织硬度信息，在鉴别诊断甲状腺微小癌方面具有一定的临床应用价值。 |
| 英文摘要: |
| ABSTRACT Objective：Virtual touch tissues quantification (VTQ) isa new elastography method which can evaluate the tissue stiffness noninvasively and quantitatively. The aim of this study is to investigate the clinical value of VTQ technique in differential diagnosis
of thyroid microcarcinomas (TMCs). Methods:Virtual touch tissue quantification (VTQ) was used to examine 114 thyroid nodules and
the adjacent thyroid tissues in 110 patients. The values of shear wave velocities (SWV) of nodules and the adjacent thyroid tissues were
obtained and analyzed. Receiver operating characteristic (ROC) curve was used to evaluate the diagnostic performance of VTQ and to
define the optimal cut-off point.Results: 114 nodules included 32 benign lesions (30 nodular goiters and2 adenomas) and 82 malignant
lesions (papillary microcarcinomas). The mean SWV in benign nodules and the adjacent thyroid tissues were 2.30 ± 0.49 m/s (range:
1.39~4.03 m/s), 2.08± 0.40 m/s (range: 1.30~2.79 m/s), respectively, while in malignant nodules and the adjacent thyroid tissues were
3.12± 0.97 m/s (range: 1. 96~8.34 m/s), 2.06± 0.46 m/s (range: 1. 05 3.13 m/s), respectively. The mean SWV of malignant thyroid nodules
was significantly higher compared with benign thyroid nodules (t=5.911, P<0.0001). A significant difference was found between malignant thyroid nodules and the adjacent tissues of thyroid (P<0.0001), while no statistical difference was found between benign thyroid nodules and the adjacent thyroid tissues (P>0.05). The area under ROC curve (AUC) was 0.833, using 2.30 m/s was the cut-off point, the
sensitivity and specificity of VTQ were 90.2 % and 62.5 %, respectively. Conclusion：Mean value of SWV of malignant thyroid nodules
were significantly higher than that of benign ones. VTQ technique could be an effective tool in the differential diagnosis of TMCs by providing quantitative infor- mation about tissue stiffness. |
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