| 王海涛朴太奎马志强王彦龙孔祥龙李兆鹏郑峰刘建宇△.干细胞治疗周围神经损伤研究进展[J].,2014,14(5):978-981 |
| 干细胞治疗周围神经损伤研究进展 |
| Research Progress in StemCell Therapy of Peripheral Nerve Injury |
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| DOI： |
| 中文关键词: 干细胞 周围神经损伤 修复 再生 |
| 英文关键词: Stemcell Peripheral nerve Injury Repair Regeneration |
| 基金项目:国家自然科学基金项目（81272015） |
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| 中文摘要: |
| 摘要：周围神经损伤是临床常见的疾病。损伤后神经的修复和再生是复杂又漫长的过程。严重的神经损伤其预后效果并不令人满
意，相应支配区域的功能难以恢复，这给患者及家人带来了极大的痛苦。因此如何更好的对周围神经损伤进行治疗一直是医学界
的难题。在神经修复机制的研究中，科学家发现施万细胞对周围神经的修复和再生起到了非常重要的作用，但获取和扩增的困难
限制了其临床的应用。随着生物医学的发展，人们把目光投向了干细胞，经实验发现干细胞不仅具有旺盛的增殖能力，而且可以
分化为神经系细胞，还能分泌相关的神经营养因子促进神经的修复和再生，这为周围神经损伤后的治疗带来了新的希望。本文就
近些年来应用于修复周围神经的干细胞及促进修复机制的研究做以综述。 |
| 英文摘要: |
| ABSTRACT:Peripheral nerve injury is a common clinical disease. The process of nerve repair and regeneration is complicated and
lengthy. The prognostic effect is unsatisfactory since the nerve function of related control area cannot restoration after severe nerve
damage. These cause great suffering to the patients and their families. Thus how to treat peripheral nerve injury better is still a major
medical problem. In the studies of nerve repair mechanism, scientists found that stem cells plays a major role in the process of nerve
repair and regeneration, but it is limited for clinical application because cells harvest and amplification is difficult. With the development
of biomedicine, scientists have set their sights on stem cells. It is found that stem cells have the ability of self-renewal and differentiation
potential of neural lineage cells. This brings us a new hopes for therapy of peripheral nerve injury. The role of stem cells and its
mechanismon repair and regeneration peripheral nerve in recent years are reviewed in this paper. |
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