| 尚磊1 张玉海1 杨显君1 孙丽君1 李怡2 江逊3△.采用三次样条拟合胎儿体格发育指标百分位数参考值[J].,2014,14(5):960-964 |
| 采用三次样条拟合胎儿体格发育指标百分位数参考值 |
| Using Cubic Smoothing Spline Fitting Physique BiometryCentile Reference for Fetus |
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| DOI： |
| 中文关键词: 胎儿 发育 百分位数 参考值 三次样条 |
| 英文关键词: Fetus Development Centile Reference value Cubic smoothing spline |
| 基金项目:国家自然科学基金项目(81273175）；陕西省科技攻关项目（2011k12-31） |
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| 中文摘要: |
| 摘要目的：生长发育评价标准的最佳形式是年龄别百分位数，然而，目前我国缺乏胎儿的孕周别体格发育指标百分位数评价标
准，影响了胎儿宫内生长发育水平的准确评价，本研究拟建立陕西省正常单胎妊娠孕妇胎儿体格发育指标百分位数参考标准。方
法：以陕西省西安、汉中、延安5 所大型综合医院超声科或妇产科超声室为数据采集点，选择2010-01-01 到2010-12-31 间进行常
规孕期检查的正常单胎妊娠胎儿的超声测量数据，随机抽取一次测量结果，共收集到6832 个单胎正常妊娠胎儿的超声测量数
据。采用三次样条法对陕西省孕16-41 周正常单胎妊娠胎儿的双顶径、腹围、股骨长百分位数进行拟合。结果：三次样条拟合胎儿
的双顶径、腹围、股骨长百分位数，各百分位数的决定系数均在0.95 以上，均方差均在各指标重复测量的容许误差内，拟合结果满
意。计算出了胎儿的孕周别双顶径、腹围、股骨长的P3、P10、P25、P50、P75、P90、P97 百分位数。结论：三次样条兼顾了曲线拟合中
的拟合优度和光滑度，能更好的实现曲线拟合的目的。所建立的孕周别胎儿体格发育指标百分位数符合胎儿宫内生长发育规律，
为胎儿宫内生长发育的准确评价提供了科学、准确的评价工具，可用于产科临床和研究工作中。 |
| 英文摘要: |
| ABSTRACT Objective:The best assessment standard for growth and development is age related centile. Presently, there is not a
centile reference standard of fetal physique index in China, this may influence the accuracy of fetal growth and development assessment.
So we want to construct centile reference of fetal biometry for singleton pregnant women in Shaanxi, China.Methods: Department of ultrosonic
or ultrasonic division of department of obstetrics and gynaecology of five large hospitals in Xi'an, Hanzhong and Yanan were selected
as data collection spot. 6,832 singleton pregnant women who have a regular pregnant examination between 2010-01-01 to
2010-12-31 in the selected hospitals were selected. One set of fetal ultrasonography measurement data between the 16th to 41th
gestational weeks was randomly selected fromeach pregnant woman, and biparietal diameter, abdominal circumference and femur length
were recorded. Centiles of biparietal diameter, abdominal circumference and femur length of fetus pregnant between 16 to 41 weeks were
directly calculated and then fitted by cubic smoothing spline.Results: All the coefficient of determination (R2) of each centile for
biparietal diameter, abdominal circumference and femur length fitted by cubic smoothing spline were all above 0.95. And all the mean
square of error of each centile for biparietal diameter, abdominal circumference and femur length did not exceed its re-measurement error
limitation. Centiles for gestational week specified P3, P10, P25, P50, P75, P90, P97 for biparietal diameter, abdominal circumference
and femur length were calculated and presented as tables.Conclusiong: Both goodness of fitting and smoothness are satisfactory for curves
fitting by the method of cubic smoothing spline. This method can realize curve fitting aim better. Reference centiles for fetal physique
indexes constructed by cubic smoothing spline were accordant with fetal growth and development rule, they were accurate tool for fetal growth and development assessment. Fetal biometry reference centiles could be used in obstetrics practice and research in Shaanxi,
China. |
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