| 王菁 姜爱民.Gankyrin 与消化系统肿瘤关系的研究进展[J].,2014,14(4):789-791 |
| Gankyrin 与消化系统肿瘤关系的研究进展 |
| Research Progress of the Relationship between Gankyrinand Digestive SystemNeoplasms |
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| DOI： |
| 中文关键词: 消化道肿瘤 癌基因 Gankyrin |
| 英文关键词: Digestive systemneoplasms Oncogene Gankyrin |
| 基金项目: |
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| 中文摘要: |
| 消化系统肿瘤与多种肿瘤相关基因的异常表达密切相关，Gankyrin 是一种癌基因，于肝癌、结直肠癌、胰腺癌等消化系统肿
瘤中高表达，并通过依赖泛素的蛋白酶解系统介导多种转录因子、细胞周期调控蛋白以及抑癌蛋白如p53、Rb 等的降解。研究表
明，Gankyrin 在消化系统肿瘤形成及细胞的生长周期调控中发挥重要作用，在消化系统肿瘤的早期诊断及判断预后方面具有一
定的应用前景，同时也可能成为消化系统肿瘤基因治疗的潜在靶点。 |
| 英文摘要: |
| The digestive systemneoplasms are associated with abnormal expression of multiple tumor related genes. Gankyrin is
an oncogene, which has been found to have high expression in the digestive system neoplasms such as hepatocellular carcinoma,
colorectal cancer, pancreatic cancer, etc. It mediates the degradation of a variety of transcription factors, cell cycle regulation proteins and
tumor suppressor proteins including p53, Rb, etc, by the protease solution system that relies on ubiquitin. Study proves that Gankyrin
plays an important role in tumorigenesis and cell cycle control of digestive system neoplasms. It has certain application prospect in the
early diagnosis and prognosis of digestive systemneoplasms and may become a promising target for therapy. |
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