| 张闿艺 盖兢泾 盖鲁粤 谢永进 管龙韬.冠心病强化标准化药物治疗最新进展[J].,2014,14(3):583-585 |
| 冠心病强化标准化药物治疗最新进展 |
| Advance in Research on Optimal Medical Therapy in CoronaryArtery Disease (Review) |
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| DOI： |
| 中文关键词: 冠状动脉粥样硬化性心脏病 强化标准化药物 经皮冠状动脉介入治疗 综述 |
| 英文关键词: Coronary artery disease Optimal medical therapy Percutaneous coronary intervention Review |
| 基金项目:“十一五”国家科技支撑计划（国科发计字[2007]184号） |
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| 中文摘要: |
| 冠状动脉粥样硬化性心脏病的患病人数呈逐年上升趋势，目前治疗冠心病的方法主要包括改善生活方式，药物治疗，经皮
冠状动脉介入治疗(PCI)和外科冠状动脉旁路移植手术治疗(CABG)。虽然介入治疗在治疗阻塞性冠心病取得了显著的进展，但因
支架再狭窄，晚期血栓形成，及未知的机制，其死亡率未见明显下降。冠状动脉旁路移植手术虽可降低死亡率，但因其为侵入性操
作及手术费用的较高成本，不能为大部分患者接受。近几年来进行了一些全球多中心的临床试验研究，以评估不同诊疗方案对冠
心病的预后及远期疗效。目前一些研究表明强化标准化药物治疗(optimal medical therapy，OMT)可与再血管化治疗同效。本文将
针对冠心病强化标准化药物治疗方面的实验研究进展进行简要综述。 |
| 英文摘要: |
| Coronary artery disease (CAD) are the main causes of disablement and mortality all over the world.The
currenttreatments for CAD includes changing lifestyle, medicaltherapy, coronary arteriography (CAG) and coronaryartery bypass grafting
(CABG).Percutaneous coronaryintervention (PCI) has achieved remarkable progress intreating obstructive CAD in the drug-eluting stent
era.However, mortality is not reduced due to late thrombosisin-stent restenosis, and unknown mechanisms. Only CABG is shown to
reduce mortality, but it was aninvasive operation with high cost. Recent years some randomized controlled trials have demonstrated that
optimal medicaltherapy (OMT) is as effective as the revascularization. Herein, the trials finding ofoptimal medicaltherapy are discussed. |
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