| 徐薇侯明英谢怀益陈敏.依那普利联合氯沙坦治疗老年肾性高血压的临床观察[J].,2012,12(27):5344-5346 |
| 依那普利联合氯沙坦治疗老年肾性高血压的临床观察 |
| Clinical Observation of Enalapril Combined with Losartan on Treatment ofElderly Renal Hypertension |
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| DOI： |
| 中文关键词: 氯沙坦 依那普利 肾性高血压 |
| 英文关键词: Losartan Enalapril Renal hypertension |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨依那普利联合氯沙坦治疗老年肾性高血压的效果。方法：选取2008 年2 月～2011 年10 月我院收治的肾性高血
压患者70 例，按随机数字表法分为观察组和对照组，每组35 例。对照组给予依那普利20mg，每天2 次；观察组给予依那普利
10mg，每天2 次；氯沙坦50mg，每天1 次。观察两组血压、肾功能指标变化及不良反应。结果：观察组总有效率为95.0%（38/35），对
照组为75.0%（30/35），差异有统计学意义（P＜0.05）；治疗后两组血压（DBP、SBP）和肾功能（SCr、BUN、mAlb）指标均明显改善
（P＜0.05），观察组较对照组改善更为明显（P＜0.05）；观察组不良反应发生为17.14%（6/35），对照组为14.29%（5/35），差异无统计
学意义（P＞0.05）。结论：依那普利联合氯沙坦治疗老年肾性高血压能更有效改善血压和肾功能，安全性高。 |
| 英文摘要: |
| Objective: To investigate the effect of enalapril combined with losartan on treatment of elderly renal hypertension.
Methods: 70 cases of patients with renal hypertension from February 2008 to October 2011 in our hospital were selected, according to the
random number table were divided into the observation group and the control group with 35 cases in each groups. The control group
were given enalapril 20mg, 2 times a day; the observation group was given enalapril 10mg, twice a day; losartan 50mg, once a day. The
blood pressure and renal function changes, and adverse reactions of two groups were observed. Results: The total effective rate of
observation group was 95.0% (38/35), in the control group was 75.0% (30/35), the difference was statistically significant (P<0.05); blood
pressure (DBP, and SBP) and renal function (SCr and BUN, mAlb) indicators were significantly improved of two groups (P<0.05),
compared wih the control group, the observation group improved more significantly (P<0.05); The occurrence of adverse reactions in the
observation group was 17.14% (6/35) , in the control group was 14.29% (5/35), the difference was not statistically significant (P>0.05).
Conclusion: Enalapril combined with losartan on treatment of elderly renal hypertension can be more effective in improving blood
pressure and renal function,and has a high security. |
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