| 刘丽娜董英伟△ 陈荣权闫全章张宁宁.辣椒辣素对大鼠急性切割痛的作用[J].,2012,12(27):5244-5247 |
| 辣椒辣素对大鼠急性切割痛的作用 |
| 辣椒辣素对大鼠急性切割痛的作用 |
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| DOI： |
| 中文关键词: 辣椒辣素 足底切口 术后疼痛 |
| 英文关键词: Capsaicin Plantar incision Post-operative pain |
| 基金项目: |
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| 中文摘要: |
| 目的：研究辣椒辣素对足底切开大鼠疼痛相关行为的影响。方法：32 只Wister 雄性大鼠随机分为四组：生理盐水组、0.05%辣
椒辣素组（C0.05）、0.1%辣椒辣素组(C0.1)、赋形剂组（吐温80），各200 微升。切开前一天足底给药，分别测定给药前的基础值，给
药后24 小时，术后2 小时及1、2、3 天对热刺激的反应，并记录累积疼痛得分，术后三天进行组织病理学评估。结果：预先给予的
辣椒辣素能够减弱热痛觉过敏和降低累积疼痛得分。组织病理学检查证实：与生理盐水比较辣椒辣素影响切口的恢复。结论：辣
椒辣素预处理具有预防术后痛的作用。对切口组织学的影响可能与药物抑制疼痛行为有关，而不一定是药物的局部作用。 |
| 英文摘要: |
| Objective: To investigate the effect of capsaicin on pain-related behavior after plantar incision in rats. Methods: 32
Wister male rats were randomly divided into four groups: the saline group, 0.05% capsaicin (C0.05)group, 0.1% capsaicin (C0.1)group,
excipient (Tween 80) group, 200 μL respectively. Administered the day before the plantar incision,determined the response to thermal
stimulation at before administration and 24 hours after administration, postoperative 2 h and 1, 2, 3 days, respectively. Recorded the
cumulative pain score and evaluated histopathology after three days. Results: Capsaicin pre-given can reduce thermal hyperalgesia and
reduced the cumulative pain score . Histopathological examination confirmed that Capsaicin affect the recovery of the incision compared
with saline. Conclusion: Capsaicin had postoperative analgesia after plantar incision, the effect on histological was likely related to its
inhibitory effects on pain behaviors and was not necessarily a local effect of the drug. |
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