| 唐利刘博强李承新△.Rab23 研究进展[J].,2012,12(26):5192-5194 |
| Rab23 研究进展 |
| Advances of Rab23 |
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| DOI： |
| 中文关键词: Rab23 Rab Hedgehog信号通路 Carpenter综合征 |
| 英文关键词: Rab23 Rab Hedgehog signaling pathway Carpenter syndrome |
| 基金项目: |
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| 中文摘要: |
| Rab23为小GTP结合蛋白，是Ras超家族Rab家族成员，其突变可引起小鼠开脑综合征（open brain syndrome），因此又称为
opb基因。它是Sonic hedgehog信号通路的负调控因子，在不同肿瘤中发挥不同作用，并参与机体组织器官的发育和分化。它可能
通过转运细胞内蛋白发挥相关作用。 |
| 英文摘要: |
| Rab23, which is also called opb gene, belongs to the small GTPase superfamily, Rab family. The mutation of Rab23
can induce open brain syndrome of mice. It is an essential negative regulator of the sonic hedgehog signaling pathway. Rab 23 have
recently been implicated in carcinogenesis, development and differentiation of tissue. The mechanism how Rab23 works may due to the
trafficking of intracellular proteins. |
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