| 董丹丹1 赵新宇2 陈文军2 王恩峰2 程明2.MSCT 灌注成像在肾细胞癌临床应用价值研究*[J].,2012,12(26):5075-5079 |
| MSCT 灌注成像在肾细胞癌临床应用价值研究* |
| The Value of Muti-slice Spiral Computed Tomography Perfusion Imagingin Diagnosis of Renal Cell Cancer* |
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| DOI： |
| 中文关键词: 肾脏肿瘤 体层摄影术 X线计算机 灌注成像 |
| 英文关键词: Kidney Renal tumor Tomography X-ray computed Perfusion imaging |
| 基金项目:黑龙江省卫生厅科研基金项目(2009-173) |
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| 中文摘要: |
| 目的：探讨肾细胞癌多层螺旋CT（MSCT）灌注成像特征，并研究其临床应用价值。方法：肾癌患者69 例，采用64 排多层螺
旋CT 对其肾脏进行平扫及灌注增强扫描，使用renal tumor perfusion 软件对图像进行后处理，自动生成时间- 密度曲线（TDC），
各种灌注图像及感兴趣区（ROI）内的灌注参数，包括血流量（BF）、血容量（BV）、平均通过时间（MTT）及表面通透性（PS），将得到
的灌注参数分别进行统计分析。结果：肾癌肿块灌注参数与已测得的正常肾皮质各灌注参数值均存在显著性差异（P值均<0.01），其
中，正常肾皮质的BF值、BV 值及PS值均高于肾癌组织，MTT 值则相反；肾癌肿块灌注参数与已测得的正常肾髓质各灌注参数
值同样存在显著性差异（p 值均<0.01），正常肾髓质各灌注参数值均低于肾癌组织，而PS 值二者之间差别不显著（P<0.05）；肾癌
患者健侧肾皮髓质灌注参数值与已测得的正常肾皮髓质各灌注参数值及肾癌患者癌旁正常肾皮髓质各灌注参数值，三者之间差
异无统计学意义（P>0.05）。结论：多层螺旋CT（MSCT）灌注成像在显示肾脏形态的同时，还可定量测量皮髓质的血流灌注情况，
间接反映肾脏生理特征。 |
| 英文摘要: |
| Objective: To study the perfusion technique of Multi-slice Sprial Computed Tomography (MSCT) and its clinical
application in malignant kidney tumors. Methods: The kidney non-enhenced imaging and perfusion imaging with 64-slice spiral CT were
performed in Sixty-eight cases of RCC（renal cell carcinoma）. Perfusion parameters of renal including blood flow（BF）, blood volume
（BV）, mean transit time（MTT）and permeability surface（PS）were computed by Perfusion software. Results: The same perfusion parameter
between renal cortex and solid components of RCCs, have significant differences (P<0.01). BF value,BV value and PS value of
renal cortex is above RCCs, but MTT value is opposite, The perfusion parameters, BF value,BV value and MTT value,between renal
medulla and solid components of RCCs have significant difference (P<0.01), but PS value has difference (P<0.05).The same perfusion
parameter among contra-lateral healthy kidney of RCCs、renal cortex and medulla and normal renal cortex and medulla of peri-RCCs,
have no significant difference(P>0.05). Conclusions: MSCT perfusion techniques can not only show the morphologie changes of the malignant
tumors,but also indicate the functional changes of the maligment tumors. The calculation of perfusion data can helpful for the
acknowledging its hemodynamic changes, As a convenient,non-invasive exam way. MSCT perfusion techniques should be applied
widely in the future. |
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