| 王晓龙1 赵娟2 杜妮2 再米热3 张忠民4.奥扎格雷钠联合依达拉奉治疗急性脑梗死的疗效观察[J].,2012,12(25):4903-4906 |
| 奥扎格雷钠联合依达拉奉治疗急性脑梗死的疗效观察 |
| Curative Effect of Ozagrel Sodium Combined with Edaravone in TreatingAcute Cerebral Infarction Patients |
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| DOI： |
| 中文关键词: 奥扎格雷纳 依达拉奉 脑梗死 |
| 英文关键词: Ozagrel sodium Edaravone Cerebral infarction |
| 基金项目: |
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| 中文摘要: |
| 目的：观察奥扎格雷钠联合依达拉奉治疗急性脑梗死的临床疗效。方法：将160 例急性脑梗死患者随机分为治疗组和对照
组，每组各80 例，治疗组采用注射用奥扎格雷钠联合依达拉奉治疗，对照组仅采用注射用奥扎格雷钠治疗，观察两组患者入院及
治疗14d 后临床疗效，神经功能缺损评分变化并进行对比分析。结果：治疗组的显效率为85.9%（67/78），对照组显效率为70.9%
（56/79），两组显效率有显著性差异（x2=5.12，P=0.022），两组患者治疗14d 后，神经功能的恢复情况与治疗前相比均有显著性差异
（P<0.05），且治疗组与对照组治疗后比较有显著性差异，具有统计学意义(P＜0.05)。结论：奥扎格雷钠联合依达拉奉治疗急性脑梗
死较单独使用奥扎格雷钠疗效显著，是治疗急性脑梗死的有效方法。 |
| 英文摘要: |
| Objective: To observe the clinical effects of Ozagrel sodium combined with Edaravone in treating acute cerebral infarction.
Methods: 160 patients (92 male and 68 female, mean age of 68years) with noncardioembolic cerebral infarction were randomly
divided into two groups, Oz-Ed Group and Control Group, 80 cases in each group. Patients in control group were administered only with
ozagrel;while patients inOz-Ed groupwere administeredwith ozagrel and edaravone.We evaluated the clinical efficacy of the combination of
these drugs in patients, and analyzed the changes of Nerve function defect score from 0 d (before treatment initiation) to 14 d. Results:
The effectual rate was 85.9%（67/78）in Oz-Ed group, and was 70.9%（56/79）in control group. There was significant difference between
the two groups, x2=5.12, P=0.022. The nerve function recovered much （P<0.05）in both groups after treated for 14 days, as compared
with that before treatment. There were also statistically significant difference between the two groups after treatment (P＜0.05). Conclusion:
Combination therapy with ozagrel and edaravone had a better effect on acute cerebral infarction than single ozagrel therapy. It is an effective
therapy for acute cerebral infarction. |
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