| 赵鑫刘艳武王雪峰△.MicroRNA 与垂体腺瘤关系的研究进展[J].,2012,12(24):4784-4786 |
| MicroRNA 与垂体腺瘤关系的研究进展 |
| ZHAO Xin, LIU Yan-wu, WANG Xue-feng |
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| DOI： |
| 中文关键词: MicroRNA 垂体腺瘤 肿瘤转化 |
| 英文关键词: MicroRNA Pituitary adenoma Tumorigenesis |
| 基金项目:黑龙江省科技厅攻关项目(GC12C304-2)；哈尔滨市科技创新人才研究专项基金（2012RFXXS069） |
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| 中文摘要: |
| MicroRNA(miRNA)是新发现的一类特殊的小分子RNA，在基因的转录后调控中扮演重要的角色。研究发现很多良恶性肿
瘤在发生发展过程中都伴有miRNA 的异常表达，所以miRNA 的转录后调控机制以及在肿瘤成瘤过程中的作用逐渐成为当下研
究的热点，本文就目前垂体腺瘤与miRNA 的研究现状做以简要概述。 |
| 英文摘要: |
| MicroRNAs (miRNAs) are small RNA molecules that play a crucial role as post- transcriptional regulators of gene
expression. There is conclusive evidence that altered miRNA expression and subsequent gene regulation in normal tissues may lead to
cancer development. In the pituitary, research has built fundamental connections between aberrant miRNA expression and neoplasia, various
findings demonstrate the immense functional range of miRNA as regulators of gene expression in the pituitary. This review will assess
the significance of miRNAs in pituitary pathology. |
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