| 韩晗1 韩延华2 张广美3.PDGF 及其受体介导的信号转导与妇科肿瘤关系研究进展[J].,2012,12(24):4757-4760 |
| PDGF 及其受体介导的信号转导与妇科肿瘤关系研究进展 |
| PDGF and its Receptor Mediated Signal Transduction Research Progressand Gynecological Tumors Relationship |
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| DOI： |
| 中文关键词: 血小板衍生生长因子 血小板衍生生长因子受体 妇科肿瘤 |
| 英文关键词: Platelet-derived endothelia cell growth factor Receptor of platelet-derived endothelia cell growth factor Gynecological
tumors |
| 基金项目:黑龙江省自然科学基金资助（ZD201110） |
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| 中文摘要: |
| 血小板衍生生长因子（Platelet-Derived Growth Factor，PDGF)是一类与生长、发育、癌症发生等密切相关的细胞因子，由多种
细胞分泌产生，具有广泛的生物学活性，涉及多种疾病。目前关于PDGF 分子结构、表达调控、生物学活性等已有较为深入的研
究，本文在介绍上述研究成果的同，对PDGF 在妇科肿瘤中的病理生理作用进一步综合分析。PDGF 参与卵泡的发生；PDGF 与子
宫肌瘤、宫颈、卵巢癌等疾病相关联。PDGF 在妇科肿瘤的发生、发展中起着重要的作用。 |
| 英文摘要: |
| Platelet-derived growth factor (PDGF ) is a kind of cytokines which is closely related with growth, development and
cancer. It is secreted by various types of cells, has a wide range of biological activity, and is involved in a variety of diseases. Current
researches on PDGF molecular structure, expression regulation, and biological activity are in-depth. This paper introduced the above
research results, and comprehensively analyzed the pathophysiological role of PDGF in gynecologic tumors. PDGF is associated with
uterine fibroids, cervical and ovarian cancer and other diseases. PDGFplayan important role in the tumorigenesis ofgynecologic tumor. |
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