| 王而强何凡曲方△.VGF 及其衍生肽[J].,2012,12(23):4572-4576 |
| VGF 及其衍生肽 |
| VGF and its Derived Peptides |
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| DOI： |
| 中文关键词: VGF 神经肽 VGF 衍生肽 抑郁症 神经变性病 |
| 英文关键词: VGF Neuropeptides VGF Derived peptides Depression Nerve degeneration |
| 基金项目:沈阳军区总医院重点科研基金课题[06Y-Z15] |
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| 中文摘要: |
| 神经肽VGF 广泛存在于中枢神经系统和外周神经系统中，在垂体、肾上腺髓质、胃肠内分泌细胞和胰岛β 细胞中亦有表
达。神经细胞/ 内分泌细胞表达VGF 多肽受到神经营养因子、神经元活性等因素的调控。目前证实，VGF 及其衍生肽参与生物体
的能量平衡、新陈代谢以及生殖发育等的凋节。在神经系统变性病及情感性精神障碍的相关研究也日益受到关注。本文就神经肽
VGF 及其衍生肽的生化、生理特性及病理生理作用做一综述。 |
| 英文摘要: |
| The neuropeptide VGF is a widespread constituent in the central and peripheral nervous system, and also expressed in
pituitary, adrenal medulla and gastrointestinal endocrine cells as well as pancreatic β cells. VGF peptides are expressed in Neurons and
endocrine cells, which regulated by neurotrophic factor, neuronal activity and other factors. It has been confirmed that VGF and its
derivatives are involved in the organism's energy balance, metabolism, reproductive development and other reactions. There is increasing
concern for VGF peptides related research in the nervous system degeneration and affective disorder. This review summarized the
biochemical and physiological characteristics of neuropeptide VGF and its derivatives and their roles in pathophysiology. |
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