| 宋艳芳张红王楚凤△ 邱霞安鑫环文英.缬沙坦对维持性血液透析患者心脏功能和结构的影响[J].,2012,12(23):4485-4487 |
| 缬沙坦对维持性血液透析患者心脏功能和结构的影响 |
| Effect of Valsartan on Cardiac Function and Structure in MaintenanceHemodialysis Patients |
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| DOI： |
| 中文关键词: 缬沙坦 血液透析 心血管疾病 |
| 英文关键词: Valsartan Hemodialysis Cardiovascular disease |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨缬沙坦对维持性血液透析(maintenance hemodialysis，MHD)患者心脏功能和结构的影响。方法：100 例MHD 患者，
随机分为治疗组（50 例）与对照组（50 例），对照组仅予基础治疗，治疗组加予口服缬沙坦治疗，总疗程为6 个月。观察治疗前后超
声心动图指标变化。结果：与治疗前及对照组同期比较，治疗组心脏结构指标左房收缩末期内径(LAD)、左室舒张末期内径
(LVDD)、室间隔厚度(IVST)、左室后壁厚度(LVPWT)、左房内径指数（LAI）、左室重量指数（LVMI）及相对室壁厚度(RWT)有所降
低，心脏功能指标：左室射血分数(LVEF)，左室短轴缩短率(FS)，二尖瓣口舒张早期和晚期最大血流速度比(E/A)值有所提高，差异
均有统计学意义(P＜0.05)。对照组超声心动图各项指标与治疗前相比变化不明显(P＞0.05)。结论：缬沙坦能延缓或逆转左心室肥
厚，明显改善左室舒张功能，有助于改善MHD 患者心脏重构，改善心脏功能，从而延缓慢性肾功能衰竭尿毒症期患者的左心室重
塑，降低心血管疾病的发生率和死亡率。缬沙坦对MHD 患者心血管疾病并发症的预防和治疗及提高MHD 患者生存率有一定临
床指导意义。 |
| 英文摘要: |
| Objective: To study valsartan on maintenance hemodialysis (MHD) patients with cardiac function and structure.
Methods: Totally 100 MHD patients were randomized into valsartan and control groups. Patients in the valsartan group were given 80mg
valsartan per day for six months. Before and after the treatment, echocardiography index were detected and the data were statistically
analyzed through SPSS16.0. Results: After 6 months, MHD patients with the treatment group cardiac structure indicators: left atrial end
systolic diameter (LAD), left ventricular end diastolic diameter (LVED), interventricular septum diastolic thickness (IVST), left
ventricular posterior wall diastolic thickness (LVPWT), left atrial diameter index (LAI), left ventricular mass index ( LVMI), relative wall
thickness (RWT) values were significantly lower than the control group, the difference was significant (P <0.05). Indicators of cardiac
function: left ventricular ejection fraction (LVEF), left ventricular fractional shortening (FS),mitral early and late diastolic peak velocity
ratio (E/A) values were significantly higher than the control group (P< 0.05), with statistical significance. Conclusions: Valsartan can
improve cardiac function and structure in MHD patients,and maybe contribute to the prevention and treatment of cardiovascular
complications in MHD patients. |
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