| 胡十齐周新伏罗自勉刘利华刘康.非霍奇金淋巴瘤患者外周血中CD4+CD25+ 调节性T 细胞
亚群变化初探[J].,2012,12(23):4479-4481 |
| 非霍奇金淋巴瘤患者外周血中CD4+CD25+ 调节性T 细胞
亚群变化初探 |
| The Exploration of Changes of CD4+CD25+ Regulatory T Cells in PeripheralBlood of Patients with Non-Hodgkin's Lymphoma |
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| DOI： |
| 中文关键词: 非霍奇金淋巴瘤 CD4+CD25+ 调节性T 细胞 外周血 变化 |
| 英文关键词: Non-Hodgkin's lymphoma CD4+CD25+regulatory T cells Peripheral blood Changes |
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| 中文摘要: |
| 目的：检测非霍奇金淋巴瘤（non-Hodgkin's lymphoma, NHL）患者外周血中CD4+CD25+ 调节性T 细胞（CD4+CD25+ regulatory
T cell，Treg）的改变，探讨Treg 与NHL 的相关性。方法：病例组（n=60）为本院收治的初诊NHL 患者，对照组（n=60）为本院健康体
检者，用流式细胞技术联合标记CD4、CD25 检测对照组及病例组化疗前、化疗后的外周血中CD4+CD25+ 调节性T 细胞的分布特
点。结果：(1)病例组化疗前外周血中CD4+ 细胞比例显著低于对照组（P<0.05），CD4+CD25+ 调节性T 细胞比例显著高于对照组（P
< 0.05）；(2)病例组化疗后，CD4+ 细胞比例明显高于化疗前（P<0.05），CD4+CD25+ 调节性T 细胞比例明显低于化疗前（P<0.05）；(3)
病例组化疗后CD4+ 细胞比例与对照组无显著差异(P>0.05)，而CD4+CD25+ 调节性T 细胞比例显著高于对照组（P<0.05）。结论：非
霍奇金淋巴瘤患者外周血中CD4+CD25+ 调节性T 细胞比例升高，存在机体免疫抑制，化疗可降低CD4+CD25+ 调节性T 细胞比
例。 |
| 英文摘要: |
| Objective: To detect the proportion of CD4+CD25+ regulatory T cells (Treg) in peripheral blood of patients with
non-Hodgkin's lymphoma(NHL), and to explore the relationship between Treg and NHL. Methods: By using flow cytometry with surface
staining fluorochrome-conjugated antibodies for CD4, CD25, the percentages of CD4+CD25+Treg in peripheral blood of 60 patients with
NHL and 60 Healthy controls were detected and analyzed. Results: ①The average peripheral blood CD4+ levels of patients with NHL
before chemotherapy was significant lower than that of the control group (P<0.05), while the percentages of CD4+CD25+Treg was
significant higher than that of the control group (P<0.05). ②After chemotherapy, the percentages of CD4+CD25+Treg was decreased and
CD4+ levels was increased than before chemotherapy. The difference between them was statistically significant (P<0.05). ③ There was
no significant difference between the control group and patients with NHL after chemotherapy of peripheral blood CD4+ level (P >0.05).
But the percentages of CD4+CD25+Treg of patients with NHL after chemotherapy was still higher than the control group(P<0.05). Conclusion:
The increase in Tregs in patients with NHL may induce immune suppression and chemotherapy may cause the decreasing of Tregs. |
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