| 赵晨1 张奕霞2.缺血缺氧疾病中脑红蛋白的表达[J].,2012,12(22):4387-4389 |
| 缺血缺氧疾病中脑红蛋白的表达 |
| The Expression of Neuroglobin in Hypoxic-ischemic Diseases |
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| DOI： |
| 中文关键词: 脑红蛋白 缺血缺氧疾病 神经保护 |
| 英文关键词: Neuroglobin Hypoxic-ischemic diseases Neuroprotection |
| 基金项目: |
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| 中文摘要: |
| 脑红蛋白是继血红蛋白和肌红蛋白后由Burmester 等[1]于2000 年发现的体内第3 类携氧蛋白，脑红蛋白在视网膜组织中的
含量高达100 μmol/L, 占视网膜总蛋白量的2 % - 4 %，其浓度约为脑中浓度的100 倍，而体内不同组织脑红蛋白表达量的增加均
与组织的缺血缺氧密切相关。视网膜作为中枢神经系统的重要组成部分之一, 对氧的需求远远大于其他神经组织,临床实践中存
在着与视网膜相关的大量的缺血缺氧性疾病, 视网膜的这种特征为我们深入研究脑红蛋白与视网膜细胞之间的关系提供了临床
基础。本文就脑红蛋白在缺血缺氧疾病中的表达展开论述，为视网膜缺血缺氧损伤中脑红蛋白的表达提供相关依据。 |
| 英文摘要: |
| Neuroglobin was discovered by Burmester in 2000 which is the third oxygen-carried protein following hemoglobin
and myoglobin. Neuroglobin in retinal tissue has a high content about 100μmol / L, accounting for 2 % - 4 % of the total protein in retina,
however, the concentration of which is approximately 100 times of that in the brain. Then the different upexpression of neuroglobin in
vivo tissues is closely related to ischemia and hypoxia injury. As one of the most essential central nervous system, the demand for oxygen
in retina is much larger than other nerve tissues. In clinical experiments,there are a lot of ischemic and anoxic diseases correlated with
the retina, which provides clinical basis for our in-depth study of the relationship between neuroglobin and retinal cells . In this paper,the
expression of neurogloubin discussed will provide the related basis for hypoxic-ischemic diseases in retina. |
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