| 李丽熊利泽孙焱芫.外周神经损伤引起的神经病理性痛：对神经损伤
的一种适应不良反应[J].,2012,12(22):4346-4379 |
| 外周神经损伤引起的神经病理性痛：对神经损伤
的一种适应不良反应 |
| Neuropathic Pain by Neural Damage to the PNS: A Maladaptive Responseof the Nervous System to Damage |
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| DOI： |
| 中文关键词: 外周神经系统 神经病理性痛 发病机制 |
| 英文关键词: Peripheral nervous system Neuropathic pain Pathogenesis |
| 基金项目:国家自然科学基金面上项目（30872434） |
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| 中文摘要: |
| 外周神经损伤可引起对神经系统的一种适应不良反应，其产生神经病理性痛的主要特点为痛觉增敏和异常疼痛。目前文献
报道多种机制涉及此反应，包括离子通道改变引起的异常放电、突触易化、多种轴突水平抑制作用缺失导致的中枢敏化、神经元
细胞的凋亡以及异常的突触连接等结构的改变，另外神经损伤引起的神经免疫之间的相互作用在神经病理性痛的持续性发展中
发挥着不可替代的作用。了解外周神经损伤引起的神经病理性的发病机制将对我们寻找治疗靶点和治疗策略提供坚实的理论基
础。 |
| 英文摘要: |
| Neural damage to the PNS provokes maladaptive responses in nociceptive pathways that drive spontaneous pain and
sensory amplification. Multiple mechanisms are responsible for neuropathic pain, including changes in ion channels that lead to ectopic
activity, synaptic facilitation, and central sensitization caused by loss of inhibition at multiple levels of the neuraxis. In addition, neuronal
cell apoptosis and aberrant synaptic connectivity provide the structural basis for persistently altered processing of both nociceptive and
innocuous afferent input. What's more, neural damage provokes vigorous and highly organized neuro-immune interactions that play a key
role in initiating many cellular mechanisms that underlie persistent neuropathic pain. It is necessary to understand the underlying
mechanisms of neuropathic pain by neural damage to the PNS, and it will guide us in the searching of treatment target and give solid
theoretic foundation for our treatment strategy. |
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