| 付志杰周华成李文志△.脑死亡诱发肺损伤机制及治疗进展[J].,2012,12(22):4373-4375 |
| 脑死亡诱发肺损伤机制及治疗进展 |
| Advancement in Mechanism and Treatment on Lung InjuryInduced Brain Death |
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| DOI： |
| 中文关键词: 脑死亡 供体 肺保护 |
| 英文关键词: Brain death Donor Lung protection |
| 基金项目:中国博士后基金特别资助项目（201104453） |
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| 中文摘要: |
| 肺移植是终末期肺疾病的最终治疗方案。供体短缺是肺移植所面临的主要问题。目前，脑死亡供体是肺移植供体的重要来
源。然而，脑死亡过程会诱发急性肺损伤并且加重肺缺血再灌注损伤。脑死亡肺损伤机制主要包括三个方面：血流动力学的剧烈
改变、全身炎症改变、神经内分泌的改变。其肺损伤表现于肺间质水肿、血浆外漏和肺泡出血，造成肺水肿等。深入探索脑死亡肺
损伤的机制，将对治疗及实施肺保护提供有力的依据。 |
| 英文摘要: |
| Lung transplantation has become an effective and a widely accepted clinical treatment for patients with end-stage
pulmonary diseases. The shortage of suitable donors is one of difficulties which are faced by lung transplantation. Brain-dead (BD) donor
is the major source of lung transplantation in recent years. Brain death is followed by devastating hemodynamic, in覱ammatory and neurohumoral
reactions in the potential donor which not only in覱ict direct damage, but also induce activation of the immune system which can
cause rejection or even graft failure. BD-induced lung injuries include massive interstitial edema, hemorrhage, and intra-alveolar deposits,
which makes the lung susceptible to ischemia-reperfusion injury, primary graft dysfunction, and chronic rejection. Hence, alleviating
BD-induced injuries can improve the outcome of lung transplantations. Further exploration of the mechanism of brain death induced lung
injury will provide strong basis for the implementation of lung protection. |
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