文章摘要
钟凌1 袁立明2△ 简晓红2.IL-4 和IFN-γ mRNA 在子痫前期患者胎盘组织中的表达及意义[J].,2012,12(22):4304-4306
IL-4 和IFN-γ mRNA 在子痫前期患者胎盘组织中的表达及意义
Expressions and Significance of IL-4 mRNA and IFN-γ mRNAin Placenta of Preeclampsia Patients
  
DOI:
中文关键词: Th1/Th2 细胞因子  IL-4  IFN-γ  子痫前期  妊娠并发症
英文关键词: Thl/Th2 cytokines  IL-4  IFN-γ  Preeclampsia  Pregnancy complications
基金项目:山东省卫生厅基金项目资助(2007HZ031)
作者单位
钟凌1 袁立明2△ 简晓红2 湖南省望城县人民医院妇产科 
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中文摘要:
      目的:检测胎盘组织中IFN-γ 和IL-4 的表达,探讨IFN-γ 和IL-4 在子痫前期的发病中的作用。方法:采用原位杂交法检测 了20 例正常妊娠孕妇和34 例子痫前期组(包括16 例轻度和18 例重度)中的IFN-γ 、IL-4 mRNA 的表达水平,并通过图像分析 系统对染色结果进行定量分析。结果: (1)IL-4 mRNA 的表达在正常妊娠组、子痫前期轻度组和子痫前期重度组的表达无差异 (P>0.05)。(2) 与正常妊娠组、子痫前期轻度组相比,子痫前期重度组IFN-γ mRNA 的表达有差异性(P<0.05);子痫前期轻度组与正 常妊娠组相比无差异(P>0.05)。(3) 与正常妊娠组相比,子痫前期轻度组、重度组IFN-γ mRNA/IL-4 mRNA 的比值均有差异性 (P<0.05),且随病情的加重比值增大。结论:Thl/Th2 细胞因子的平衡偏离可能是导致子痫前期发病的病因之一。
英文摘要:
      Objective: To detect the expressions of IL-4 mRNA and IFN-γ mRNA in placenta of preeclampsia patients, and to explore the cause of preeclampsia. Methods: Patients with preeclampsia were chosen as the study group and normal pregnancy as and control group. The placental Th1-type cytokines IFN-γ mRNA and Th2-type cytokines IL-4 mRNA of the two groups are marked with in situ hybridization method, and the staining results were quantitatively detected and compared by color pathology image analysis system. Results:(1) The expressions of IL-4 mRNA were not statistically different between normal pregnancy group, mild preeclampsia group and severe preeclampsia group (P>0.05). (2) Compared with normal pregnancy group and mild pre-eclampsia group, the expression of IFN-γ mRNA was significantly different in severe pre-eclampsia group (P <0.05); There was no difference between the mild preeclampsia group and normal pregnancy group (P>0.05). (3) Compared with normal pregnancy group, the IFN-γ mRNA/IL-4 mRNA ratio had difference in mild and severe preeclampsia group (P<0.05), and increased along with disease severity. Conclusion: The imbalance of Th1/Th2 cytokine may be one of the causes for preeclampsia.
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