| 张志南1 韩凤山1 韩正凯1 鹿双岭1 刘玉梅2.陀螺旋转式立体定向放射治疗联合NP 方案治疗局部晚期非小细胞肺癌
的临床疗效观察[J].,2012,12(21):4046-4049 |
| 陀螺旋转式立体定向放射治疗联合NP 方案治疗局部晚期非小细胞肺癌
的临床疗效观察 |
| Gyro Rotary Stereotactic Radiotherapy Combined NP Treatment SchemeLocally Advanced Non-small cell lung cancer Clinical Curative Effects |
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| DOI： |
| 中文关键词: 局部晚期非小细胞肺癌 陀螺旋转式立体定向放射治疗系统 长春瑞滨 顺铂 |
| 英文关键词: Locally advanced non-small cell lung cancer Gyro rotary stereotactic radiotherapy Changchun Rachel shore Cisplatin |
| 基金项目:黑龙江省教育厅科学技术研究项目（11541114） |
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| 中文摘要: |
| 目的：观察陀螺旋转式立体定向放射治疗系统（陀螺刀）联合长春瑞滨、顺铂（NP）方案治疗局部晚期非小细胞肺癌(NSCLC)
的临床疗效观察及毒副反应。方法：94 例局部晚期NSCLC 患者，先给予陀螺刀治疗，单次治疗剂量3. 2-5. 0 Gy,等剂量曲线50 %
-70 %,计划靶体积(PTV)覆盖95 %以上，总剂量35-50 Gy,治疗后进行NP 方案化疗4-6 个周期。与同期144 例单纯陀螺刀治疗局
部晚期NSCLC 患者治疗结果相比较。结果：联合治疗的94 例患者, 近期有效率为86.17 %(81/94), 6、12 和24 个月生存率分别为
86.17 % (81/94)、60.64 % (57/94)和36.17 % (34/94)，毒性反应较轻。同期单纯陀螺刀治疗患者,近期有效率为88.19 %(127/144), 6、
12 和24 个月生存率分别为87.50 % (126/144)、44.44 % (64/144)和23. 68 % (33/144)。结论：陀螺刀联合NP 方案是一种对局部晚
期NSCLC 比较有效的治疗方法,毒副反应较轻。 |
| 英文摘要: |
| Objective:Observe gyro rotarystereotactic radiotherapy(gamma-SRT) joint changchunRachel sedimentation and cisplatin
(NP) treatment scheme locally advanced non-small cell lung cancer (NSCLC) the clinical curative effect of the observation and adverse
reaction. Methods: 94 cases of patients with locally advanced NSCLC, first give gamma-irradiation SRT treatment, a single treatment
dose 3. 2 - 5. 0 Gy, etc dose curve 50%-70%, and plans to target volume (PTV) covers more than 95%, total doses 35 to 50 Gy, treatment
after 4-6 cycles of chemotherapy NP scheme. Compared with the 144 cases of pure gamma-irradiation SRT treatment for patients with locally
advanced NSCLC compared treatment results. Result: Combination therapy of 94 patients, recent effective rate was 86.17% (81/94),
6, 12 and 24 months survival rates were 86.17% (81/94), 60.64% (57/94) and 36.17% (34/94), toxic reaction is lighter. Only the same period
gamma-irradiation SRT treat the patient, recent effective rate was 88.19% (127/144), 6, 12 and 24 months survival rates were 87.50%
(126/144), 44.44% (64/144) and 23. 68% (33/144). Conclusion: Gamma-irradiation SRT joint NP scheme is a local advanced-stage
NSCLC does more effective treatments, adverse reaction is lighter. |
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