| 梁秀云蒙春华莫诚航区倩萍邝敏.支气管哮喘患者血清IL-4、TNF-α 及IgE 水平变化及临床意义[J].,2012,12(20):3864-3866 |
| 支气管哮喘患者血清IL-4、TNF-α 及IgE 水平变化及临床意义 |
| Clinical Significance of Detecting Serum Levels of IL-4, TNF-α,IgE in Patients with Bronchial Asthma |
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| DOI： |
| 中文关键词: 支气管哮喘 IL-4 TNF-α IgE |
| 英文关键词: Bronchial asthma IL-4 TNF-α IgE |
| 基金项目: |
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| 中文摘要: |
| 目的：研究支气管哮喘患者白细胞介素-4（IL-4）、肿瘤坏死因子-α（TNF-α）及免疫球蛋白E（IgE）水平变化及临床意义。方
法：对78 例支气管哮喘患者（急性发作期组39 例、缓解期组39 例）血清IL-4、TNF-α、IgE 水平进行检测，并与正常对照组的40 例
健康受试者进行比较分析。结果：支气管哮喘患者组血清IL-4、TNF-α、IgE 水平显著高于正常对照组，差异均有统计学意义（P<
0.05）；急性发作期组血清IL-4、TNF-α、IgE 水平均显著高于缓解期组，差异亦均有统计学意义（P<0.05）；支气管哮喘患者血清
IL-4、TNF-α、IgE 水平两两之间呈正性显著相关（P<0.05）。结论：检测支气管哮喘患者血清IL-4、TNF-α、IgE 水平对患者疾病预测
及治疗具有重要的临床意义。 |
| 英文摘要: |
| Objective: To study the clinical significance of detecting serum levels of IL-4, TNF-α, IgE in patients with bronchial
asthma (BA). Methods: The serum levels of IL-4, TNF-α, IgE were detected in 78 patients (39 patients with BA in acute exacerbation, 39
patients with BA in remission), and compared with those of 40 healthy subjects in the control group. Results: The serum levels of IL-4,
TNF-α, IgE in the BA group were significantly higher than those in the control group (all P<0.05). The serum levels of IL-4, TNF-α, IgE
in the acute exacerbation group were significantly higher than those in the remission group (all P<0.05). The serum levels of IL-4, TNF-α
were actively correlated each other.(P<0.05). Conclusion: The detection of serum levels of IL-4, TNF-α, IgE play an important role in
disease prediction and treatment of patients with BA. |
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