| 胡艳茹匡洪宇△.自噬在2 型糖尿病和胰岛β 细胞中作用研究进展[J].,2012,12(19):3738-3740 |
| 自噬在2 型糖尿病和胰岛β 细胞中作用研究进展 |
| The Progression of Role of Autophagy in Pancreatic Beta Cells and Diabetes |
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| DOI： |
| 中文关键词: 自噬 2 型糖尿病 胰岛β 细胞 |
| 英文关键词: Autophagy Type-2 diabetes Pancreatic bete cells |
| 基金项目: |
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| 中文摘要: |
| 胰岛素分泌缺陷和胰岛素抵抗是2 型糖尿病发病的主要机制之一。高血糖和脂质代谢紊乱，是糖尿病发病机制中最重要的
获得性因素。最近研究表明自噬在维持内环境稳定，胰岛β 细胞数量分泌能力，及对抗胰岛素抵抗等方面有重要作用。本文就自
噬的基本概念及在糖尿病发病和维持β 细胞功能方面作一综述。 |
| 英文摘要: |
| Disrupted pancreatic β-cell function and decreased β-cell number are two of the main causes of type 2 diabetes.
glucotoxicity and lipotoxicity are the most important acquired character associated with type 2 diabetes. Recent studies have indicated
that autophagy plays an important role in maintaining internal environment stabilization ,number ,secretive function of pancreatic β-cell
and counteracting insulin resistance. In this paper ,we review the concept of autophagy and its role in pancreatic β-cells and type-2
diabetes. |
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