| 韩明杨允林宏宇黄艺娜.前体蛋白转化酶家族的重要成员之一：弗林蛋白酶[J].,2012,12(18):3586-3588 |
| 前体蛋白转化酶家族的重要成员之一：弗林蛋白酶 |
| An Important Member of the Family of Proprotein Convertases: Furin |
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| DOI： |
| 中文关键词: 弗林蛋白酶 内切蛋白酶 前体蛋白 |
| 英文关键词: Furin Endoprotease Proprotein |
| 基金项目:福建省自然科学基金资助项目（2009J01127） |
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| 中文摘要: |
| 弗林蛋白酶（Furin）是前体蛋白转化酶家族的重要成员之一，广泛存在于各种组织和细胞系中。Furin 经过两次自剪切去掉
前肽后具有生理活性，能够识别特定的氨基酸序列并在TGN 中对多种前体蛋白进行加工。Furin 的作用底物不仅包括神经肽和肽
类激素，还包括许多生长因子、受体、血浆蛋白酶、基质金属蛋白酶及细菌外毒素等，具有重要的生物学功能。 |
| 英文摘要: |
| Furin is a key member of the family of proprotein convertases, which is expressed in all tissues and cell lines. It will
gain its bioactivity after two self-cleavages and activate many other proproteins into their biologically active forms in the trans-Golgi network,
because it can identify the specific amino acid sequence. Furin possesses important biological functions as it is capable of cleaving
precursors of a wide variety of proteins, not only neuropeptides and peptide hormones, but also many growth factors,receptors, plasma
proteases, matrix metalloproteinases and bacterial exotoxins. |
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