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目的：探讨急性呼吸道感染患儿白细胞（WBC）计数、血清内毒素（ET）、C 反应蛋白（CRP）水平变化及临床应用价值。方法：对急性呼吸道感染组106 例患儿（细菌感染组62 例、病毒感染组44 例）进行WBC 计数、血清ET、CRP 水平等指标进行检测，并与正常对照组的40 例健康儿童进行比较分析。结果：急性呼吸道感染组患儿WBC 计数、血清ET、CRP 水平均显著高于正常对照组，差异具有统计学意义（P<0.05 或P<0.01）；血清ET、CRP 水平对诊断脓毒症的敏感性差异无显著性（P>0.05），均显著高于 WBC 计数，差异具有统计学意义（P<0.05）；WBC 计数特异性显著高于ET、CRP 水平，ET 水平特异性显著低于CRP，差异均具有统计学意义（P<0.05）；细菌感染组患儿血清ET、CRP 水平显著高于病毒感染组，差异具有统计学意义（P<0.05），而两组间WBC 计数差异不显著（P>0.05）。结论：测定WBC 计数、ET、CRP 对急性呼吸道感染患儿具有一定的诊断价值。

英文摘要:

Objective: To detect the alteration of WBC count, ET and CRP levels for acute respiratory tract infection children in clinical diagnosis. Methods: The WBC count, ET and CRP levels were detected in 106 acute respiratory tract infection patients (62 children infected with bacterial, 22 children infected with virus), and 40 healthy children were as control. Results: The WBC count, ET and CRP levels in infected group were significantly higher than those of control group, the difference was statistically significant (P<0.05 or P<0.01). The sensitivity of ET, CRP in the diagnosis of acute respiratory tract infection was not statistically different (P>0.05), but it was significantly higher than that of WBC count, the difference was statistically significant (P<0.05). The specificity of WBC count was significantly higher than ET and CRP, the difference was statistically significant (P<0.05); the specificity of ET was significantly lower than CRP, the difference was statistically significant (P<0.05). The ET and CRP levels in the bacterial infected group were significantly higher than virus infected group, the difference was statistically significant (P<0.05), but the WBC count had no significant difference between the two groups (P>0.05). Conclusions: TheWBC count, ET and CRP levels have significant correlation with the diagnosis of acute respiratory tract infection.

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