| 史林1 文益民2△ 李含1 魏祥科1 张涛1.京尼平或紫外线交联制备的壳聚糖/ 藻酸盐复合支架材料比较[J].,2012,12(18):3442-3445 |
| 京尼平或紫外线交联制备的壳聚糖/ 藻酸盐复合支架材料比较 |
| 京尼平或紫外线交联制备的壳聚糖/ 藻酸盐复合支架材料比较 |
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| DOI： |
| 中文关键词: 京尼平 壳聚糖 藻酸盐 复合支架材料 |
| 英文关键词: Genipin Chitosan Alginate Composite scaffold material |
| 基金项目:全军医学科学技术研究" 十一五" 计划课题项目（06MA081） |
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| 中文摘要: |
| 目的：比较京尼平或紫外线交联的壳聚糖/ 藻酸盐复合支架材料的降解率、孔隙率、含水量、细胞毒性以及生物力学等特性。
方法：①按照交联方法不同分为：京尼平组、紫外线组。②扫描电镜下观察材料的表面结构以及检测材料的降解率、孔隙率、含水
量、细胞毒性以及生物力学。结果：①紫外线组与京尼平组均表现为多孔隙结构，无明显差异。②紫外线组降解率高于京尼平
组。③京尼平组与紫外线组的孔隙率差异无统计学意义，含水量差异比较有统计学意义。④两组均表现为较低的细胞毒性，良好
的生物相容性。⑤京尼平交联组的生物力学特性较紫外线组显著提高。结论：京尼平交联的壳聚糖/ 藻酸盐复合支架材料，具有
良好的生物学特性，为组织工程脊髓领域提供了非常具有潜力的材料。 |
| 英文摘要: |
| Objective: To investigate genipin (GP) or ultraviolet rays (UV) crosslinking effect on chitosan/alginate composite
scaffold material for tissue engineering by comparing their degradation rate, porosity, water content, cytotoxicity and biomechanics
properties. Methods: ①According to different cross-linking methods, biomaterials were divided into (GP)group, (UV)group. ②The
surface structure of two groups was detected by scanning electron microscope (SEM). The material degradation rate, porosity, water
content, cytotoxicity, and biomechanics properties were detected. Results: ①both UV group and GP group showed pore -rich structure,
and there was no significant difference between the two groups. ②Degradation rate of UV group was higher than that of GP group. ③GP
group and UV group had no significant difference in porosity. The difference of water content is meaningful in Statistics. ④GP group and
UV group showed low cytotoxicity, good biocompatibility. ⑤Biomechanics properties of GP group were significantly improved
compared with UV group. Conclusion: Genipin crosslinked chitosan/alginate composite scaffold material has good biological
characteristics. It is a potential material in tissue engineering of spinal cord field. |
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