| 曲峻锋禹亮△.肺癌与DNA 甲基化研究的进展[J].,2012,12(17):3384-3387 |
| 肺癌与DNA 甲基化研究的进展 |
| Advances of DNA Methylation and Lung Cancer |
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| DOI： |
| 中文关键词: 肺癌 基因甲基化 去甲基化治疗 |
| 英文关键词: Lung Cancer Gene Methylation Demethylation |
| 基金项目:黑龙江省教育厅基金项目（11541134） |
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| 中文摘要: |
| DNA 甲基化是表观遗传学研究的重要内容。其本质是在甲基转移酶的催化下，DNA 的CG 两个核苷酸的胞嘧啶被选择性
地添加甲基，形成5' 甲基胞嘧啶的过程。CpG 岛是DNA 甲基化常发生的部位。CpG 岛指基因组中长度为300～3000 bp 的富含
CpG 二核苷酸的一些区域，主要存在于基因的5' 区域。以往的研究表明，肺癌的发生常与CpG 岛的异常甲基化有关。多基因异常
的甲基化常为肿瘤发生的重要机制。近年来，研究比较热门的基因有p16、RASSF1A、CDH1、CDH13、FHTI、TMS1/ASC 等。研究集
中在肺癌组织与癌旁组织甲基化频率的统计分析，以及对于血液，痰液，肺泡灌洗液发生甲基化频率的统计分析。对于肺癌相关
抑癌基因甲基化的研究，为肺癌患者的早期诊断提供思路，并为治疗开辟新的方向。去甲基化治疗虽研究较少，但目前已取得一
定进展。 |
| 英文摘要: |
| DNA methylation is an important part of Epigenetics. In action of methyltransferase, Cytosine of nucleotide CG is
added by methyl Selectively, Formed 5'-mC. The area of dna methylation is constantly CpG island. CpG island is the area riched with
dinucleotide, which has the longth of 300-3000 bp,located at genomic 5'region. Previous studies have shown that the incidence of lung
cancer is often associated with abnormal methylation of the CpG island. Multiple gene aberrant methylation is often as important
mechanism of tumor. In recent years, research of popular gene as p16, RASSF1A, CDH1, CDH13, FHTI, TMS1 / ASC etc. The study
foucs on statistical analysis of lung cancer tissue and paracancerous tissue methylation frequencies,and analysis of blood, sputum,
bronchoalveolar lavage fluid methylation frequencies. For lung cancer tumor suppressor gene methylation related research, provide a
train of thought of patients with lung cancer in the early diagnosion, and for new direction of the treatment. Demethylation therapy is less
studied, but it has achieved some progress. |
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