| 陈双1 甘冠华2 楚凤婷3 冯齐平3.颊粘膜癌与舌癌差异基因表达的对比分析[J].,2012,12(16):3144-3146 |
| 颊粘膜癌与舌癌差异基因表达的对比分析 |
| Differences of Gene Expression Profile between Buccal MucosaCancer and Tongue Cancer |
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| DOI： |
| 中文关键词: 颊粘膜癌 舌癌 基因表达 |
| 英文关键词: Buccal mucosa cancer Tongue cancer Gene expression |
| 基金项目:2010 年上海基础研究计划（10ZR1432199） |
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| 中文摘要: |
| 目的：研究颊粘膜癌(Buccal Mucosa Cancer, BMC)与舌癌(Tongue Cancer, TC)的基因差异表达，探讨BMC 与TC 发生发展
的基因学基础。方法：应用cDNA 芯片技术对5 例BMC 和5 例TC 组织mRNA 检测，通过芯片杂交、生物信息学处理，找出两者
间差异表达基因。结果：BioStarH-40 芯片发现差异表达基因503 条，差异表达基因占12.9％ ，其中表达增强274 条(显著增强69
条)，表达降低229 条(显著降低54 条)。结论：MBC 与TC 基因表达比较，差异有统计学意义，这些差异可能在两类肿瘤不同的生
物学行为中起重要作用。 |
| 英文摘要: |
| Objective: To determine the difference in the gene expression between human buccal mucosa cancer (BMC) and
tongue cancer (TC). Methods: cDNA chip was used to detect the mRNA of cancer tissue from 5 BMCs and 5 TCs. After profile bloted
and handled by bioinformation, the gene expression of these two kinds of lesions was examined. Results: Using the BioStarH-40 profile,
503 different expression of genes were found. The rate of different genes was 12.9%, of which the exprssion of 274 genes increased(69
genes significantly increased) and 229 genes decreased (54 genes significantly decreased ) in BMC tissue than that in TC. Conclusions:
The gene expression ofBMCandTCwas different,whichmaycontribute to the different biological behavior ofthese two kinds oflesions. |
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