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目的：探讨母体与脐血清白介素-17(interleukin-17 IL-17)与妊娠期糖尿病发病（gestational diabetes mellitus GDM）及新生儿出生体重相关性。方法：收集我院足月GDM 患者26 例为病例组，孕24-28 周经50g 葡萄糖筛查试验无异常者26 例为对照组，分娩前收集两组母血清及脐血清，检测母血清空腹血糖及空腹胰岛素，稳态模型评估胰岛素抵抗（homeostasis model assessment insulin resistance HOMA-IR）。检测两组母血清及脐血清IL-17 水平，探讨与妊娠期糖尿病发病及新生儿出生体重相关性。结果： GDM 组空腹胰岛素、HOMA-IR、母血清IL-17、脐血清IL-17 与对照相比具有统计学差异（P<0.05）。相关研究发现，母血清IL-17 水平与HOMA-IR 存在明显正相关（r=0.718，P<0.001），脐血清IL-17 与新生儿体重存在相关性（r=0.686 P<0.001），但脐血清IL-17 水平与母血清IL-17 水平无相关性（r=-0.339, P=0.0899）。结论：IL-17 可能通过胰岛素抵抗参与了GDM 的发生。

英文摘要:

Objective: To evaluate maternal and cord blood serum IL-17 in gestational diabetes mellitus (GDM) and its correlation with neonatal birth weight. Methods: To collect 26 term GDM in our hospital as case group, and 26 cases with no abnormal 50g glucose challenge test in 24-28 weeks as control group. Maternal serum before delivery and cord blood serum were collected. Fasting blood glucose testing and fasting insulin, homeostasis model assessment insulin resistance (HOMA-IR) were tested in maternal serum. IL-17 levels were detected in maternal serum and cord blood serum to explore the pathogenesis of gestational diabetes and its correlation with neonatal birth weight. Results: Fasting insulin, HOMA-IR, IL-17 in maternal serum, IL-17 in cord blood serum had significant difference in GDM group compared with control (P<0.05). It was found that maternal serum IL-17 levels existed positively correlated with HOMA-IR (r = 0.718, P <0.001), IL-17 in cord blood serum was correlated with neonatal birth weight (r = 0.686 P <0.001), but IL-17 in cord blood serum had no correlation with maternal serum levels (r =- 0.339, P = 0.0899). Conclusion: IL-17 may be involved in insulin resistance with the occurrence of GDM.

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