| 朱庆峰左维泽△ 刘佩芝季榕田群詹爱琴.I b 型慢性丙肝患者血清IL-10、IL-12 水平
与HCV-RNA 载量关系的研究*[J].,2012,12(15):2946-2948 |
| I b 型慢性丙肝患者血清IL-10、IL-12 水平
与HCV-RNA 载量关系的研究* |
| Relationship between the Serum Levels of IL-10、IL-12 and HCV-RNA Loadin Chronic Hepatitis C GenotypeⅠb Patients* |
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| DOI： |
| 中文关键词: 慢性丙肝 IL-10 IL-12 HCV-RNA |
| 英文关键词: Chronic hepatitis C Interleukin 10 Interleukin 12 Hepatitis C virus ribonucleic acid |
| 基金项目:新疆生产建设兵团重点领域科技攻关（2011BA054） |
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| 中文摘要: |
| 目的：研究I b 型慢性丙肝患者血清IL-10、IL-12 水平与HCV-RNA 载量的关系，探讨难治性丙肝的免疫发病机制。方法：选
取HCV-RNA 阳性的I b 型慢性丙肝患者48 例，依据病毒载量将其分为三个组，低病毒载量组（1.0*103IU/mL＜HCV-RNA≤
1.0*104IU/mL）15 例、中病毒载量组（1.0*104IU/mL＜HCV-RNA≤1.0*106IU/mL）20 例、高病毒载量组（HCV-RNA＞1.0*106IU/mL）
13 例，另选HCV-RNA 阴性的慢性HCV 感染者15 例，健康献血员15 例作为对照组；应用ELISA 法检测所有研究对象的血清
IL-10、IL-12 水平。结果：慢性丙肝患者外周血IL-10 水平显著高于健康献血员(P=0.003)，IL-12 水平低于健康献血员(P=0.045)；随
着HCV-RNA 载量的升高，HCV-RNA 阳性的I b 型慢性患者外周血IL-10 水平逐渐升高，组间比较差异具有统计学意义（F=18.
65，P=0.000）；血清HCV-RNA 载量与血清IL-10 水平呈正相关(相关系数r=0.71, P=0.000)，与血清IL-12 水平无相关性(P=0.479)。
结论：慢性HCV 感染者与患者的细胞免疫均倾向于TH2 型；I b 型慢性丙肝患者外周血IL-10 水平与HCV-RNA 病毒载量呈正
相关。 |
| 英文摘要: |
| Objective: To study the relationship between the serum levels of IL-10、IL-12 and HCV-RNA load in chronic hepatitis
C genotypeI b Patients，to investigate the mechanism of difficult-to-treat HCV patients. Methods: 48 cases chronic hepatitis C genotype I
b patients were divided into 3 groups, low virus load group:15 cases (1.0*103IU/ml＜HCV-RNA≤1.0*104IU/ml)，medium virus load
group: 20 cases (1.0*104IU/ml＜HCV-RNA≤1.0*106IU/ml)，high virus load group: 13 cases (HCV-RNA＞1.0*106IU/ml); 15 cases
serum HCV-RNA-negative patients with chronic hepatitis C virus infection and 15 cases healthy blood donors as control groups . Serum
IL-10 and IL-12 levels were determined by ELISA method in all cases. Results: The level of IL-10 in serum of patients with chronic
hepatitis C was significant higher than that in control groups (P=0.003), and the level of IL-12 was just significant lower than healthy
blood donors group (P=0.045); the level of IL-10 was stepped up with the increase of HCV-RNA load, it was different significantly
among 5 groups (F=18.65，P=0.000); Between the level of IL-10 and the HCV-RNA load are positive correlation, the level of IL-12 and
the HCV-RNA load are noncorrelation. Conclusion: Cell immunity of chronic hepatitis C genotype I b patients tend to TH2 type; there is
a positive correlation between the level of IL-10 and the HCV-RNA load. |
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