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目的：探讨基层医院应用固尔苏联合鼻塞持续气道正压通气（NCPAP）防治新生儿呼吸窘迫综合征（NRDS）的疗效及可行性。方法：预防组23 例，为胎龄＜32 周有NRDS 高危因素的早产儿，应用固尔苏及NCPAP；治疗组35 例，为已发生NRDS 的早产儿，应用固尔苏及NCPAP；对照组22 例，单用NCPAP 治疗。监测治疗前及治疗后1、12、24、48 小时的血气分析，对其氧疗时间、住院时间、住院费用、并发症进行分析。结果：治疗组氧疗时间、住院时间、住院费用及并发症均显著低于对照组（P<0.05）。预防组 NRDS 发生率显著低于对照组，固尔苏治疗后1、12、24、48 小时FiO2 显著低于固尔苏治疗前(P<0.05) 。结论：早期应用固尔苏联合NCPAP 能有效预防和治疗NRDS，减少并发症及住院费用，其方法安全可行，适合在有条件的基层医院推广。

英文摘要:

Objective: To determine the effect of Curosurf combined with nasal continuous positive airways pressure (NCPAP) for neonatal respiratory distress syndrome (NRDS). Methods: 23 premature infants (less than 32 weeks gestational age) with NRDS dangerous factors were administrated with Curosurf and NCPAP as prevention group; 35 premature infants with NRDS were administrated with Curosurf and NCPAP as treatment group; 22 premature infants with NRDS were administrated only with NCPAP as control group. Blood gas analysis was measured before treatment, and 1h,12h,24h, 48 hr after treatment. Duration of oxygen inhalation, hospitalization time and cost, incidence of complications were compared among these three groups. Results: Compared with control group, we observed significant shorter oxygen inhalation duration, shorter hospital stay, less cost, lower incidence of complications in the treatment group(P<0.05). The incidence of NRDS was lower in the prevention group as compared to the control group. FiO2 requirement decreased at 1h,12h, 24h, 48h after Curosurf treatment (P<0.05). Conclusions: Early administration of Curosurf with NCPAP can prevent and treat NRDS, decrease complication incidence, and reduce cost. It is safe to apply in primary hospitals.

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