| Objective: To explore the effect of flavonoids chemical Luteolin to the insulin resistance induced by the high fat diet in
the mice. Methods: 30 mice were divided into three groups, the normal chow group (10 mice), the high fat diet group (10 mice), the high
fat diet+2%Luteolin group, the intervention time is 16 weeks. The body weight, lipids levels, blood glucose level, insulin sensitivity and
the variation of insulin were detected. Results: After administration of 16 weeks high fat diet, the body weight, the blood glucose level,
the lipids level and the insulin level were significantly increased in mice of the high fat diet group, and the insulin sensitivity were
decreased, compared with the Luteolin group, P<0.05 or P<0.01. In the Luteolin group, the body, lipids level, blood glucose level and
insulin level increased slightly when compared with the control group, but no significantly difference exist, P >0.05. Conclusion: Luteolin
can prevents the mice insulin resistance induced by high fat diet. |
