| 段素萍1 刘剑2 赵桂娥1 王俊鹏3 徐兴森4△.不同剂量阿司匹林干预对非ST 段抬高性急性冠脉综合征患者机体炎症
水平及血管内皮功能的影响[J].,2012,12(13):2545-2548 |
| 不同剂量阿司匹林干预对非ST 段抬高性急性冠脉综合征患者机体炎症
水平及血管内皮功能的影响 |
| Curative Effect Observation of Inflammation Level and Endothelial Functionon the Non-ST-Segment Elevation in Acute Coronary Syndrome withDifferent Doses of Aspirin |
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| DOI： |
| 中文关键词: 冠状动脉粥样硬化性心脏病 急性冠脉综合征 炎症因子 阿司匹林 |
| 英文关键词: Coronary heart disease Acute coronary syndrome Inflammatory factor Aspirin Endothelial function |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨不同剂量阿司匹林对接受保守治疗的非ST 段抬高性ACS 患者机体炎症水平及血管内皮功能的影响，为ACS
患者阿司匹林的应用提供更充分的临床依据。方法：200 例患者以不稳定型心绞痛和非ST 段抬高性心肌梗死分层后随机分2 组，
阿司匹林高剂量治疗组，阿司匹林低剂量治疗组。阿司匹林高剂量组患者在入院给予300mg 阿司匹林负荷后继以150mg/d 治疗。
阿司匹林低剂量组患者入院给予150mg 负荷后继以75mg/d 维持，两组患者其余基础的治疗一致。患者在入院时及干预1 周后，
抽取静脉血检测患者血炎症因子hs-CRP、IL-6、TNF-α 及反应血管内皮功能的NO、ET-1 的变化。结果：① 经治疗后，2 组患者的
炎症因子水平均显著下降，P<0.05 或P<0.01；同时发现高剂量阿司匹林具有更显著的抗炎及改善血管内皮功能的作用，两组间指
标比较，差异显著，P<0.05。②在因出现不良反应而终止试验的人数方面，两组间无显著性差异，P>0.05。结论：高剂量阿司匹林具
有更显著拮抗机体炎症及改善血管内皮功能的作用，值得在ACS 患者的治疗中进行推广应用。 |
| 英文摘要: |
| Objective: In order to provide more clinical information to the application of aspirin in patients with ACS, we explore
the effects of different doses of aspirin on non-ST segment elevation ACS patients' inflammatory levels and vascular endothelial function.
Methods: 200 cases of ACS were divided into two levels, the unstable angina and non-ST segment elevation myocardial infarction, then
divided into two groups, the aspirin high dose group, the aspirin low dose group. For aspirin high dose group, patients were given 300mg
aspirin first, and then 150mg aspirin each day. For aspirin low dose group, patients were given 150mg aspirin first, and then 75mg aspirin
each day, all the other base therapy on the same. The observation time is 7 days. All the patients took blood from the vein to detect the inflammatory
factor the hs-CRP,IL-6,TNF-α,and the NO,ET-1. Results: After 7 days treatment, inflammatory cytokines were significantly
decreased in patients of the two groups, P <0.05 or P <0.01; high-dose aspirin treatment has more pronounced anti-inflammatory and improved
endothelial function, P <0.05. As for the patients number terminated due to the adverse reactions in trials, the two groups showed
no significant difference, P> 0.05. Conclusion: High-dose aspirin has more pronounced antagonistic inflammatory and improve the role of
vascular endothelial function, it is worth to promote the application in the treatment of patients with ACS. |
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