| 刘沙1 陆燕2 王立山3 刘欣1 万琪1△.奥卡西平对偏头痛大鼠三叉神经节神经元钙电流的影响*[J].,2012,12(13):2474-2477 |
| 奥卡西平对偏头痛大鼠三叉神经节神经元钙电流的影响* |
| Oxcarbazepine Inhibited the High Voltage Active Calcium Currents ofTrigeminal Ganglion Neurons with Sensitization of Dural Afferents |
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| DOI： |
| 中文关键词: 奥卡西平 偏头痛 三叉神经节神经元 全细胞膜片钳 钙电流 |
| 英文关键词: Oxcarbazepine Migraine Trigeminal ganglion neurons Whole cell patch clamp Calcium currents |
| 基金项目:国家自然科学基金项目（81070896） |
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| 中文摘要: |
| 目的：研究奥卡西平(Oxcarbazepine,OXC )对大鼠三叉神经节神经元钙电流的调控作用。方法：SD 大鼠随机分为3 组(n=8):
生理盐水组(NS 组)，致炎剂组(IS 组)，OXC 预防组。应用膜片钳技术，采用全细胞记录方式，观察OXC 对偏头痛大鼠急性分离的
三叉神经节的高电压激活钙电流(HVA-ICa)的调控作用。结果：OXC 能够抑制钙电流，使钙电流的激活曲线向去极化方向移动，使
钙电流的失活曲线向超级化方向移动。结论：OXC 可能通过抑制钙离子进入细胞膜，来预防偏头痛的发作。同时OXC 可能对外周
神经系统及伤害感受的传入的兴奋性起到调控作用。 |
| 英文摘要: |
| Objective: The aim of the present study was to investigate the effects of Oxcarbazepine (OXC) on high voltage active
calcium currents in trigeminal ganglion neurons in rat model of migraine. Methods: Male adult Sprague Dawley rats were randomly divided
into 3 groups (each group n=8): normal saline treatment group, IS infusion group, OXC prevention group. We report the effects of
OXC on calcium currents, using a conventional whole-cell patch clamp technique fromacutely isolated rat trigeminal ganglion neurons.
Results: OXC inhibited calcium currents. Moreover, OXC could shift the voltage-gated activation curve for calcium channel in the depolarizing
direction; shift the steady-state inactivation curve for calcium channel in the hyperpolarizing direction. Conclusion: OXC, whose
preventative action in migraine prophylaxis may involve blockade of Ca2+ entry across the cell membrane, prevent migraine efficiently.
Considering its complex modulatory effects on voltage-gated calcium channels, OXC might have potential effects on the nervous system
and lead to a change in excitability of nociceptive afferent fibers. |
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