连帅彬戴宪华△.衰老癌症基因稳定性与干细胞肿瘤特性[J].,2012,12(12):2391-2396 |
衰老癌症基因稳定性与干细胞肿瘤特性 |
Aging, Cancer, Genome Stability and Tumorigenicity of Stem Cells |
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DOI: |
中文关键词: 衰老 癌症 基因稳定性 胚胎干细胞 多功能干细胞 |
英文关键词: Aging Cancers Genome Stability HESCs HiPSCs |
基金项目:国家自然科学基金(Grant 61174163) |
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中文摘要: |
衰老和癌症一直是生物医学研究的热点,诱发衰老和癌症的原因很多,为了攻克衰老与癌症的难题,科学家们对多功能干
细胞进行大量的研究,但是发现多功能干细胞也具有致瘤特性。本文从DNA 稳定性的角度出发,综合最新的研究成果,对当前生
物医学领域的研究热点进行了系统的综述,主要包括DNA 损伤与修复机制,造成衰老的因素,癌症的特性,以及胚胎干细胞与多
功能干细胞的肿瘤特性等。 |
英文摘要: |
Aging and cancer are always the hot research points of bioinformatics and medical for many years, which can be
induced by a mount of reasons. In order to cope with difficulties, scientists have done many researches on Pluripotent Stem Cells (PSC) .
However, the PSCs also have tumorigenicities. In this paper, from the perspective of DNA stability, we review the hot research points in
biomedicals including: the types of DNA damage and repair, the reasons for aging, the characteristics of cancers, the tumorigenicities of
human embryonic stem cells (HESCs) and human induced pluripotent stem cells (HiPSCs). |
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