| 褚雨霆陈信义△ 王荣华王婧.白血病干细胞自我更新信号通路相关基因表达与白血病复发[J].,2012,12(11):2195-2197 |
| 白血病干细胞自我更新信号通路相关基因表达与白血病复发 |
| The Gene Expression of Self-renewal Signal Pathways in LeukaemiaStem Cells and Leukemia Relapse |
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| DOI： |
| 中文关键词: 急性白血病 白血病干细胞 信号通路 |
| 英文关键词: Acute leukemia Leukaemia stem cells Signal pathway |
| 基金项目:教育部高等学校博士点专项基金（20100013110008）；北京中医药大学自主创新课题（2010YYBZZ-XS071） |
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| 中文摘要: |
| 除骨髓移植外，以化疗为主的急性白血病治愈率很低，尤其因耐药复发的难治性急性白血病不能治愈的原因是患者体内存
在一群具有自我更新能力的白血病干细胞。虽然这些细胞数量极少，但可自我更新，具有很强的增殖潜能，在白血病发生和复发
过程中起着关键性作用。白血病干细胞的存在和增殖受细胞表面分子、细胞调控信号通路、细胞自我更新信号通路与骨髓微环境
等多因素影响，其中，细胞自我更新信号通路及其相关基因表达在维系白血病干细胞生物学特征方面发挥着重要作用 |
| 英文摘要: |
| In addition to the bone marrow transplantation, the cure rate of acute leukemia mainly with chemotherapy is very low.
Especially because of the acute leukemia of drug resistance relapsing refractorily cannot be cured is existing self-renewal ability of
leukaemia stem cells of a group of patients. Although these very few number of cells can self-renewal, and have a strong potential proliferation
in leukemia relapse, and play a key role in the process. The existing and proliferation of Leukaemia stem cells are due to surface
molecules, cellular control signal pathways, cell self-renewal signal pathways and bone marrow micro environment factors.Among these
factors, the cell self-renewal signal pathways and its gene expression in maintaining leukaemia stem cell biology characteristics play a
major role. |
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