| 崔金兴1 崔国方2△ 钟志欢3 张积涛2 陈惠2.山东地区肾上腺素能β3 受体基因多态性与冠心病的相关性研究[J].,2012,12(11):2141-2144 |
| 山东地区肾上腺素能β3 受体基因多态性与冠心病的相关性研究 |
| Relationship between β3-Adronergenil Receptor Genetic Polymorphismand Risk Factors of CHD Patients in ShanDong Region |
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| DOI： |
| 中文关键词: 冠心病 肾上腺素能β3 受体 基因突变 |
| 英文关键词: CHD β3-adronergenil receptor Genetic polymorphism |
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| 中文摘要: |
| 目的：研究山东地区肾上腺素能β3 受体(β3-AR)基因多态性与冠心病及其危险因素的之间的关系。方法：对相互间无一级
亲属关系的120 例冠心病患者及114 例非冠心病正常对照组人群，进行体重指数、腰臀围比、空腹血糖、血脂、血压、心电图、心脏
彩超等检测，同时应用聚合酶链反应- 限制性片段长度多态性（PCR-RFLP）核苷酸分型技术检测肾上腺素能β3 受体基因及其基
因多态性进行分析。结果：（1）冠心病组和正常对照组Trp64Trp、Trp64Arg 和Arg64Arg 的基因型频率分别为68.3％，30.0％，1.6％
和69.2％，29.8％，0.9％。冠状动脉粥样硬化性心脏病组Arg 等位基因频率(16.6%)与对照组(15.8%)频率近似(P>0.05),突变频率在
冠心病与非冠心病之间相比无显著性差异。（2）多态性分布在冠状动脉粥样硬化性心脏病组不同冠脉病变支数亚组中也无显著
性差异(x2=0.471，P=0.790)。结论：肾上腺素能β3 受体基因Trp64Arg 突变与山东地区人群冠心病的发生、发展无明显相关性。 |
| 英文摘要: |
| Objective: To investigate the Relationship between β3- adronergenil receptor genetic polymorphism and risk factors of
patients with coronary heart disease （CHD）in Shandong region. Methods: The 120 patients with coronary heart disease and 114 healthy
controls were involved in the study. These β3-adronergenil receptor genetic polymorphisms were analyzed by PCR-restriction fragment
length polymorphism (PCR-PFLP). The indexes such as body weight , height, Body-mass index (BMI), waist circumstance, hip circumstance,
blood pressure , lipids, fast plasma glucose and electrocardiogram were detected in all subjects. Results: (1) The frequen- cies of
Trp/Trp, Trp/Arg andArg/Arg were 68.3％,30.0％,1.6％ in the CHD group while those were 69.2％,29.8%And 0.9％ in the control
group. The frequency of Arg allele were 16.6% in the CHD group and 15.8% in the control group(P>0.05).(2) The frequencies of Trp/Arg
and Arg/Arg genotypes of the Trp64Arg polymorphism were not statistically different among CHD patients with one, two and three or
more significantly diseased vessels (x2=0.471，P=0.790). Conclusion: The findings suggest no significant association was found betweenβ3-
AR Trp64Arg polymorphism and CHD in ShanDong region. |
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