| 李堃1 邓靖1 时艳1 田建会2 于新波1△.中、重度牙周炎与冠心病患者白细胞介素17 及血脂水平的比较[J].,2012,12(11):2085-2090 |
| 中、重度牙周炎与冠心病患者白细胞介素17 及血脂水平的比较 |
| Comparative Study of Interleukin-17 and Lipid Levels in the Patientswith Moderate to Severe Periodontitis and CHD |
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| DOI： |
| 中文关键词: 白细胞介素17 牙周炎 冠状动脉疾病 危险因素 |
| 英文关键词: Interleukin (IL)-17 Periodontitis Coronary disease Risk factors |
| 基金项目:青岛市科技局基金（KED-13）；国家自然科学基金项目（81100755） |
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| 中文摘要: |
| 目的：研究汉族人群中、重度牙周炎与冠心病的相关性并初步探讨白细胞介素17 在二者相关性中的可能作用。方法：检测
和分析40 名健康者(健康组)、40 例中、重度牙周炎患者(牙周炎组)、28 例冠状动脉粥样硬化性心脏病患者(冠心病组)及47 例患冠
心病伴中、重度牙周炎的患者(冠心病+ 牙周炎组)血清白细胞介素17 水平、血脂水平(血清低密度脂蛋白、高密度脂蛋白、胆固
醇、总胆固醇和甘油三酯)和牙周临床指数(附着丧失、探诊深度和探诊出血)。结果：单因素方差分析结果显示，健康组、牙周炎组、
冠心病组及牙周炎+ 冠心病组的血清白细胞介素17 水平分别为(13.01±1.23)、(24.45±2.13)、(59.90±2.23)和(68.87 ±3.43)ng／
L，各组血清白细胞介素17 间的差异具有统计学意义(P<0.05)，且经协方差分析校正年龄、受教育状况、血压和体重指数后显示，
各组血清白细胞介素17 水平间的差异仍具有统计学意义(P<0.05)。多元Logistic 回归分析结果显示，中、重度牙周炎患者发生冠
心病的可能性高于牙周健康者，其发生冠心病的相对风险率比值比为2.416(P=0.039；95％CI：1.126-6.659)。经协方差分析校正年
龄、受教育状况、血压和体重指数后，各组血清总胆固醇水平间差异仍具有统计学意义(P=0.018)。结论：严重的牙周感染可能通过
改变白细胞介素17 水平，影响全身炎症反应和冠心病的发生及发展，可能是冠心病事件的危险因素之一。 |
| 英文摘要: |
| Objective: To investigate the relationship between moderate or severe periodontitis and coronary hean disease(CHD)
and study the function of serum Interleukin (IL)-17 levels in the two diseases in China. Methods: The Serum IL-17, serum lipids levels
and clinical periodontal parameters in 155 patients were detected into 4 groups: 40 patients with moderate or severe periodontitis, 28 patients
with the CHD and 47 with periodontitis and CHD and 40 healthy numbers as the control group. The serum lipids contains the low
density lipoprotein-cholesterol(LDL-C), the high density lipoprotein-cholesterol(HDL-C), total cholesterol(TC)and triglyceride(TG). The
clinical periodontal parameters contains clinical attachment loss(CAL), probing depth (PD), and bleeding on probing(BOP). Results: The
serum IL-17 levels in control group, moderate or severe periodontitis patients, CHD patients and patients with both diseases were
(13.01±1.23 ), (24.45±2.13), (59.90±2.23) and (68.87 ±3.43) ng/L, respectively. The differences among these four groups were statistical
significance (P<0.05). The multivariate logistic regression revealed that the possibility of CHD in periodontitis patients was higher
than that in the healthy group (OR=2.416 95％CI:1.126-6.659). The total cholesterol levels were also significantly different among the
four groups (P=0.018). Conclusions: The severe periodontitis could affect the happening and development of Systemic inflammation and
CHD by changing the interleukin 17 levels, which should be a risk factor for CHD. |
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