| 杨净2 谭志红1 赵柯1△.瘦素与糖尿病母亲婴儿关系的研究进展[J].,2012,12(9):1785-1787 |
| 瘦素与糖尿病母亲婴儿关系的研究进展 |
| The Research of Relationship between Leptin and Infant of Diabetic Mother |
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| DOI： |
| 中文关键词: 瘦素 糖尿病 妊娠 免疫 |
| 英文关键词: Leptin Diabetes Gestation Immunity |
| 基金项目: |
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| 中文摘要: |
| 在机体中，瘦素可通过调节脂肪的沉积，而参与能量代谢，同时在生殖、造血、免疫调节和神经内分泌系统等方面发挥着重
要的作用。研究发现，瘦素在糖尿病母亲婴儿体内的表达会增高，且浓度在胎儿及新生儿期发生动态的变化。同时，瘦素与其体重
及畸形发病率也存在一定的联系。另有研究显示，瘦素浓度与新生儿免疫功能密切相关，而糖尿病母亲婴儿体内的高瘦素水平必
然会给其免疫系统带来一定的影响。由此可以看出，瘦素对糖尿病母亲婴儿产生着深刻的影响，所以其在临床诊疗中的应用有着
非常大的意义。糖尿病母亲婴儿出生后及时瘦素的监测及采取相应的应对措施，对于其并发症的发生起到防治的作用。同时，糖
尿病母亲在孕期血糖的控制，可以减少瘦素的分泌，从而减少并发症的发生。 |
| 英文摘要: |
| In the body, leptin can regulate fat deposition, and involved in energy metabolism, and reproductive, hematopoietic,
immune and neuroendocrine systems has played an important role. The study found that leptin in vivo expression of infants of diabetic
mother may increase, and the concentration of fetal and neonatal period occurred dynamic changes. At the same time, there are some
links between leptin and its weight and the incidence of malformations. Another study showed that leptin concentrations are closely related
to neonatal immune function, and the high leptin levels in the body of infants of diabetic mother would have some impact on the immune
system. It can be seen, leptin has a profound impact on infants of diabetic mother, so its application in clinical practice has a very
large significance. Timely monitoring of leptin and taking corresponding measures can prevent the occurrence of complications after
birth. Meanwhile, the control of blood glucose during pregnancy the diabetes mother can reduce the secretion of leptin, thereby reducing
the incidence of complications. |
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