| 白晓芳黄天霞罗艳林洁张瓒.阿托伐他汀治疗慢性阻塞性肺疾病改善肺功能的临床效果分析[J].,2012,12(9):1722-1724 |
| 阿托伐他汀治疗慢性阻塞性肺疾病改善肺功能的临床效果分析 |
| The Clinical Effects of Improving Lung Function for AtorvastatinTreatment of Chronic Obstructive Pulmonary Disease |
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| DOI： |
| 中文关键词: 慢性阻塞性肺疾病 阿托伐他汀 肺功能 |
| 英文关键词: Chronic obstructive pulmonary disease Atorvastatin Lung function |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨阿托伐他汀对改善慢性阻塞性肺疾病肺功能的临床效果。方法：60 例C0PD 患者随机分为对照组组和治疗组各
30 例，对照组给予常规治疗，治疗组在对照组的基础上口服阿托伐他汀(20mg/d)。两组患者随访12 周，比较分析两组患者肺功能
改善情况及生活质量的变化情况。结果：两组治疗前肺功能无明显差异，治疗后两组肺功能较治疗前均有显著改善。治疗组较对
照组第1 秒用力呼气容积(FEVl)、用力肺活量(Fvc)、FEVl／FVC 和FEVI 占预计值百分比(FEVl％Pred)等明显改善，差异有显著的
统计学意义（P＜0.01）；并且生活质量评分治疗组明显高于对照组，差异有显著的统计学意义（P＜0.01）。结论：阿托伐他汀能明显
提高慢性阻塞性肺疾病的肺功能，提高患者的生活质量。 |
| 英文摘要: |
| Objective: To investigate The clinical effects of improving lung function for Atorvastatin treatment of chronic obstructive
pulmonary disease. Methods: Sixty C0PD patients were randomly divided into control group and treatment group,30 patients in each
group. Control group received conventional therapy, the treatment group were given the oral administration of atorvastatin (20mg / d)
based on conventional therapy, Patients were followed up for 12 weeks, And improvement in lung function and quality of life changes in
tow groups were compared. Results: There were no significant differences in lung function before treatment in tow groups. Lung function
after treatment in two groups were significantly improved. The forced expiratory volume in one second (FEVl), forced vital capacity
(Fvc), FEVl / FVC and FEVI% predicted (FEVl% Pred) in treatment group were significantly improved than in the control group, the difference
was statistically significant (P<0.01). And quality of life score was significantly higher than the control group, the dif- ference was
statistically significant (P<0.01). Conclusions: Atorvastatin can significantly improve lung function and life quality of patients with chronic
obstructive pulmonary disease. |
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