| 耿琳张云明李晔张国欣王新华韩辉△.老年痴呆与血浆同型半胱氨酸水平关系的临床研究[J].,2012,12(9):1683-1685 |
| 老年痴呆与血浆同型半胱氨酸水平关系的临床研究 |
| The Clinical Research of Plasma Homocysteine Levels in Senile Dementia |
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| DOI： |
| 中文关键词: 老年痴呆 同型半胱氨酸 认知障碍 |
| 英文关键词: Senile dementia Homocysteine Cognitive disorder |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨血浆同型半胱氨酸(homocysteine，Hcy)水平与老年痴呆的相关性。方法：应用全自动生化分析仪以循环酶法检测
90 例老年痴呆患者的血浆Hcy 浓度，并与30 例非痴呆患者作为同龄对照组血浆Hcy 浓度进行比较；根据Hachinski 缺血指数量
表评分将老年痴呆分为阿尔茨海默病(Alzheimer's disease，AD)，混合性痴呆(mixed dementia，MD)，血管性痴呆(vascular dementia，
VD)；根据简易精神状态检查量表(Mini-Mental State Examination，MMSE)评分划分痴呆患者严重程度，分为轻度、中度、重度。结
果：AD、MD、VD 组血浆Hcy 水平均显著高于对照组(P<0.01)；不同程度痴呆患者血浆Hcy 水平有显著性差异(P<0.05)，血浆Hcy
浓度越高，认知功能损害的程度越重。结论：高Hcy 血症可能是老年期痴呆发病的一个重要危险因素，且认知功能减退的程度与
血浆同型半胱氨酸浓度呈正相关。 |
| 英文摘要: |
| Objective: To investigate the relationship between plasma homocystetine (Hcy) level and dementia. Methods: The
plasma Hcy levels in 90 cases of senile dementia and 30 non-demented controls were determined by automatic biochemical analyzer with
enzymatic cycle detection. According to Hachinski ischemic score patients were divided into Alzheimer's disease (Alzheimer's Alzheimer
disease, AD), mixed dementia (mixed dementia, MD), vascular dementia (vascular dementia, VD). The severity of dementia patients
were classi- fied by MMSE's scores: mild .moderate and severe. Results: Mean total plasma Hcy concentrations were significantly higher
in AD.MD.VD patients than that in the patients with non-demented patients (P<0.01). Plasma Hcy was different significantly in dementia
patients with different severities of cognitive disorder (P<0.05). The higher the plasma Hcy concentration, the more severe of degree of
cognitive dysfunction. Conclusion: Hyperhomocysteinemia (Hhcy) may be an important risk factor of senile dementia. Hcy level is positively
corre- lated with the severity of cognitive disorder in patients with dementia. |
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