| 范红伟卢瑗瑗吴琼顾勇安艳新王新.Ran 在胃癌中的表达及其临床意义[J].,2012,12(8):1490-1494 |
| Ran 在胃癌中的表达及其临床意义 |
| Expression of Ran and Clinicopathological Parametersin Gastric Carcinoma |
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| DOI： |
| 中文关键词: Ran 胃癌 小G 蛋白 |
| 英文关键词: Ranr Gastric cancer Small G Protein |
| 基金项目:国家自然科学基金：(30973410) ；国家自然科学基金面上项目：(30971337) |
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| 中文摘要: |
| 目的：利用免疫组织化学的方法探讨小G 蛋白Ran 在胃癌中的表达及临床意义。方法：利用免疫组织化学染色法研究74 例
胃癌组织标本（其中高分化25 例，中分化24 例，低分化25 例）及其毗邻正常组织中Ran 的表达情况，并分析该蛋白表达水平与
临床病理参数之间的关联。结果：（1）Ran 在胃癌组织中的染色强度明显高于正常组织。（2）在癌组织中Ran 表达于胞核和胞浆，
其中又以胞核为主，在正常组织中Ran 主要表达于胞浆。（3）Ran 的表达与患者年龄、性别无相关性（0.464、0.912），与肿瘤分化、
TNM 分期和转移与否有显著相关性（0.001、＜0.001、＜0.001）。结论：与正常组织相比，Ran 在胃癌组织中的表达显著增高，并且
与肿瘤分化和病理分期存在显著正相关，其可能作为胃癌新的分子标志物，在肿瘤的发生发展中发挥重要作用。 |
| 英文摘要: |
| Objective: To investigate the expression of the small G protein Ran in gastric cancer and its clinical significance.
Methods: Immunohistochemistry was used to detect the expression of Ran in 74 cases of gastric tumor tissues, among which there were
25 well-differentiated cases, 24 moderately- differentiated cases, and 25 poorly-differentiated cases, and their adjacent normal tissues.
Analyze the relevance between the expression and the clinic pathological parameters. Results: (1)Ranwas expressed greater in gastric cancer
tissues than in normal gastric mucosa by immunohistochemical study. (2) In gastric cancer tissues, Ran was expressed in both nucleus
and cytoplasm, but mainly in nucleus. However, in normal tissues, its expression was localized in cytoplasm. (3) Expression of Ran had
no correlation with the patients' age and gender (p=0.464, 0.912), but was positively correlated with tumor differentiation (P=0.001),
invasion (P＜0.001), and pathological stage (P＜0.001). Conclusion: Ran expression is up-regulated in gastric cancer and positively
correlated with tumor differentiation and pathological stage. It could be taken as a new potential biomarker of gastric cancer, and may
play an important role in the development of gastric cancer. |
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