| 唐微朱建思△.EB 病毒LMP1 在肿瘤研究中的进展[J].,2012,12(7):1394-1397 |
| EB 病毒LMP1 在肿瘤研究中的进展 |
| Advancement of Epstein-Barr Virus-Encoded LMP1 in Tumor |
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| DOI： |
| 中文关键词: EB 病毒 潜伏性膜蛋白1 肿瘤 |
| 英文关键词: Epstein-Barr virus Latent membrane protein 1 Tumor |
| 基金项目: |
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| 中文摘要: |
| EB 病毒（Epstein-Barr virus，EBV）是具有致瘤潜能的疱疹病毒，与多种恶性肿瘤的发生相关。EB 病毒编码的潜伏性膜蛋白
1（Latent membrane protein-1，LMP1）作为其主要的致瘤蛋白，能通过细胞内多种信号传导通路，调节和控制细胞的生长、增殖、分
化、迁移与凋亡，从而在癌变的发生和发展过程中发挥重要的作用。本文主要就LMP1 的结构、生物学功能、介导的信号通路及其
与肿瘤关系的相关进展做一阐述。 |
| 英文摘要: |
| Epstein-Barr virus is a kind of herpes virus that has oncogenic potential and is related to the tumor genesis process of
various malignancy. Epstein-Barr virus-encoded LMP1 plays an important role in the pathogenesis and development of cancer, which as
the main oncogenic protein of EBV, through a variety of intracellular signal transduction pathways to regulate and control cell growth,
proliferation, differentiation, migration and apoptosis. This article mainly reviews its structure, biological function, signaling pathway and
the related progress with tumor. |
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