| 曾明民谭红波梁志军曾晚蓉△ 李辉.重症急性胰腺炎患者早期肠内营养治疗的作用及价值探讨[J].,2012,12(6):1129-1132 |
| 重症急性胰腺炎患者早期肠内营养治疗的作用及价值探讨 |
| Investigation on the Effect and Value of Early Enteral Nutrition onPatients with Severe Acute Pancreatitis |
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| DOI： |
| 中文关键词: 重症急性胰腺炎 肠内营养 血浆内毒素 TNF-α |
| 英文关键词: Severe acute pancreatitis Enteral nutrition Plasma endotoxin TNF-α |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨经鼻空肠管早期行肠内营养( EN)在重症急性胰腺炎( S AP)治疗中的作用。方法：40 例SAP 患者随机分为治疗组
和对照组，每组各20 例，对照组给予常规治疗，治疗组在常规治疗的基础上加用肠内营养。观察两组治疗前后血清白蛋白和淀粉
酶水平、血浆内毒素及肿瘤坏死因子TNF-α 水平的变化情况。考察治愈率症、感染率、病死率、平均住院时间及费用。结果：治疗组
患者行肠内营养后，血浆内毒素、TNF-α 下降速度明显快于对照组P<0.05，感染率、平均住院时间与费用明显降低。结论：EN 能改
善ASP 患者的营养状况，改善肠道黏膜屏障及降低炎性细胞因子分泌来加强治疗效果，是SAP 重要治疗手段。 |
| 英文摘要: |
| Objective: To investigate the effect of early enteral nutrition via nasogastrojejunal tube in treatment of severe acute
pancreatitis (SAP). Methods: 40 patients with SAP randomly divided into treatment group and control group, 20 cases in each group. The
control group were given general treatment, and the treatment group were given general treatment plus enteral nutrition. The plasma endotoxin,
serum albumin and amylase levels and tumor necrosis factor (TNF-α) were observed before and after treatment. The cure rate,
infection rate, fatality rate, average hospital stays and costs were also observed and analyzed. Results: After treated with enteral nutrition,
the plasma endotoxin and TNF-α levels of patients in treatment group decreased significantly faster than those in control group (P<0.05).
The infection rate, average hospital stays and costs were also induced much. Conclusion: Enteral nutrition therapy can improve the
intestinal mucosal barrier and reduce secretion of inflammatory cytokines to enhance the therapeutic effect. So it is important in treating
patients with SAP. |
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