郭俊1 杨华强2△.COX-2 与血液恶性疾病[J].,2012,12(4):784-787 |
COX-2 与血液恶性疾病 |
COX-2 and Hematological Malignant Disease |
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DOI: |
中文关键词: 环氧化酶- 2 肿瘤 淋巴瘤 白血病 骨髓瘤 |
英文关键词: Tumor Lymphoma Leukemia Myeloma |
基金项目:湖北省教育厅基金资助(B20092404) |
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中文摘要: |
环氧化酶(COX-2)是体内前列腺素(PG)合成过程中重要的限速酶,它在正常组织中表达甚少, 但在肿瘤和炎性细胞中表达
较多, 近年来的研究表明COX-2 的过表达与肿瘤的发生,发展有关,使COX-2 成为肿瘤研究的新热点,但COX-2 在实体肿瘤中
的研究较多而与血液恶性疾病之间关系国内报道较少,现就COX-2 的研究进展以及在血液恶性肿瘤中的作用做一综述。 |
英文摘要: |
Cycloxygenase-2 (COX-2),which expressed little in normal tissues ,but mainly expressed in tumor and Inflammatory
cell, was a rate-limiting enzyme in prostaglandin synthesis. Recent studies showed the expression of COX-2 was associated with
development and progression of tumor, and it made COX-2 a investigative hot spot.There were a lot of studies about COX-2 in solid
tumors, but there were little studies about COX-2 in hematological malignant disease. Now we make a review for COX-2 research
progression and its role in hematological malignant disease. |
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