| 田刚1 雷宁2 王晓娟3 樊明新1 陈祖容4 韩瑞军1 曾庆乐2 夏永勤1 李华1△.姜黄素抑制大鼠C6 胶质瘤生成及机制初步研究[J].,2012,12(4):635-637 |
| 姜黄素抑制大鼠C6 胶质瘤生成及机制初步研究 |
| The Inhibitive effect of Curcumine on Implanted C6Neurogliocytoma in Rats |
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| DOI： |
| 中文关键词: 姜黄素 胶质瘤 NF-κB EGFR |
| 英文关键词: Curcumine Neurogliocytoma NF-κB EGFR |
| 基金项目:广东省食品药品职业学院院级课题（2009YZ001） |
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| 中文摘要: |
| 目的：观察姜黄素对大鼠C6 胶质瘤的抑制作用。方法：将SD 大鼠随机分为假手术组、模型组、姜黄素高、低剂量组。各组动
物于移植术后7 天给予干预，姜黄素组给予姜黄素灌胃，14 天后处死。分离肿瘤测量其体积，realtime RT-PCR 法和western blot 法
检测肿瘤组织中核转录因子-κB(nuclear factor-κB,NF-κB)、EGFR mRNA 和蛋白的表达。结果：姜黄素能明显降低肿瘤体积，降
低肿瘤组织中NF-κB、EGFR mRNA 和蛋白的表达。结论：姜黄素能抑制大鼠C6 胶质瘤的生长，其机制可能与抑制NF-κB、
EGFR 表达有关。 |
| 英文摘要: |
| Objective: To study the effect of curcumine on implanted neurogliocytoma in rats. Methods: Sprague Dawley rats
were divided into normal group, sham operated group and three curcumine groups. Contents of NF-κB and EGFR protein and mRNA
were detected by immunohistochemical and real-time PCR methods, respectivly. Results: In curcumine groups, Contents of NF-κB and
EGFR protein and mRNA were decreased markedly. Conclusion: Curcumine could inhibit the implanted neurogliocytoma in rats. This
maybe be concerned with that it could inhibit the expression of NF-κB and EGFR in the implanted neurogliocytoma in rats. |
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